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Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Anticoagulation in Chronic Kidney Disease.
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Hospital Marina Salud, Denia, Alicante, Spain.
Article Synopsis
- The management of anticoagulation in chronic kidney disease (CKD) patients is complex due to increased risks of bleeding and clotting, necessitating careful dosing and monitoring.
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Indoor tent management for extending honey bee research season: benefits and caveats.
J Insect Sci
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Department of Biological Sciences, Wehr Life Sciences, Marquette University, Milwaukee, WI, USA.
Honey bees are important organisms for research in many fields, including physiology, behavior, and ecology. Honey bee colonies are relatively easy and affordable to procure, manage, and replace. However, some difficulties still exist in honey bee research, specifically that honey bee colonies have a distinct seasonality, especially in temperate regions.
View Article and Find Full Text PDFNewer treatments for diabetes mellitus: A caveat with rapid glycaemic improvement and caution regarding changes in retinopathy screening guidelines within the UK NHS programme.
J R Coll Physicians Edinb
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Opthalmology Department, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent, UK.
A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΦGT mice.
BMC Neurosci
February 2024
Department of Immunology, Genetics and Pathology, Uppsala University, 815, Husargatan 3, Uppsala, 751 08, Sweden.
Background: A pseudotyped modified rabies virus lacking the rabies glycoprotein (G-protein), which is crucial for transsynaptic spread, can be used for monosynaptic retrograde tracing. By coupling the pseudotyped virus with transgene expression of the G-protein and the avian leukosis and sarcoma virus subgroup A receptor (TVA), which is necessary for cell entry of the virus, researchers can investigate specific neuronal populations. Responder mouse lines, like the RΦGT mouse line, carry the genes encoding the G-protein and TVA under Cre-dependent expression.
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