Following vaccination against rubella, persons are sometimes detected who, despite repeated rubella vaccinations (Cendehill strain), show absence of seroconversion in the HAI or HIG test. Eighteen female probands, showing no serological antibody response on two occasions, by the above test methods after vaccination, demonstrated seroimmunity before vaccination documented by neutralising antibodies against rubella virus in serum samples, or a booster effect induced by the vaccination. The reason for these apparent vaccination failures could be a residual immunity following either rubella infection in utero or in earliest childhood.
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