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Atmospheric pollution affects the morphoanatomical and physiological responses of plants in urban Atlantic Forest remnants.
Environ Sci Pollut Res Int
January 2025
Departamento de Biologia Vegetal, Universidade Federal de Viçosa, Viçosa, MG, 36570-900, Brazil.
The Metropolitan Area of São Paulo (MASP) in southern Brazil is impacted by high ozone levels posing significant threats to its urban forests and the Atlantic Forest remnants. These green areas, covering 540 km and constituting 30% of MASP's territory, necessitate an urgent assessment of air pollution impacts on their flora. Our study investigates the effects of atmospheric pollution on the morphoanatomical and physiological responses of four native tree species (Alchornea sidifolia, Casearia sylvestris, Guarea macrophylla, and Machaerium nyctitans) across two Atlantic Forest remnants in MASP.
View Article and Find Full Text PDFStudy Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.
Cureus
January 2025
Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, GBR.
Background: Obsessive-compulsive disorder (OCD) is a complex condition marked by persistent distressing thoughts and repetitive behaviours. Despite its prevalence, the mechanisms behind OCD remain elusive, and current treatments are limited. This protocol outlines an investigative study for individuals with OCD, exploring the potential of psilocybin to improve key components of cognition implicated in the disorder.
View Article and Find Full Text PDFPsychophysical assessment of color vision with the Cambridge Color Vision Test in unilateral functional amblyopia.
Arq Bras Oftalmol
January 2025
Research Nucleus in Neuroscience and Behavior and Applied Neuroscience, Universidade de São Paulo, São Paulo, SP, Brazil.
Purpose: Amblyopia is a cortical neurological disorder caused by abnormal visual experiences during the critical period for visual development. Recent works have shown that, in addition to the well-known visual alterations, such as changes in visual acuity, several perceptual aspects of vision are affected. This study aims to analyze and compare the effects of different types of amblyopia on visual color processing and determine whether these effects are correlated with visual acuity.
View Article and Find Full Text PDFMeta-analysis of retinal transcriptome profiling studies in animal models of myopia.
Front Med (Lausanne)
January 2025
Department of Ophthalmology, Emory University, Atlanta, GA, United States.
Objective: Myopia prevalence is increasing at alarming rates, yet the underlying mechanistic causes are not understood. Several studies have employed experimental animal models of myopia and transcriptome profiling to identify genes and pathways contributing to myopia. In this study, we determined the retinal transcriptome changes in response to form deprivation in mouse retinas.
View Article and Find Full Text PDFNLRX1 limits inflammatory neurodegeneration in the anterior visual pathway.
J Neuroinflammation
January 2025
Department of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Chronic innate immune activation in the central nervous system (CNS) significantly contributes to neurodegeneration in progressive multiple sclerosis (MS). Using multiple experimental autoimmune encephalomyelitis (EAE) models, we discovered that NLRX1 protects neurons in the anterior visual pathway from inflammatory neurodegeneration. We quantified retinal ganglion cell (RGC) density and optic nerve axonal degeneration, gliosis, and T-cell infiltration in Nlrx1 and wild-type (WT) EAE mice and found increased RGC loss and axonal injury in Nlrx1 mice compared to WT mice in both active immunization EAE and spontaneous opticospinal encephalomyelitis (OSE) models.
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