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Genome-wide analysis of Smad and Schnurri transcription factors in demonstrates widespread interaction and a function in collagen secretion.
Elife
January 2025
Department of Biology, Queens College, CUNY, New York, United States.
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the transforming growth factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) family, yet only a small number of direct target genes have been well characterized. In the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade. Here, we identify functional binding sites for SMA-3/Smad and its transcriptional partner SMA-9/Schnurri based on ChIP-seq peaks (identified by modEncode) and expression differences of nearby genes identified from RNA-seq analysis of corresponding mutants.
View Article and Find Full Text PDFWhy has the 'miracidium' of Notocotylidae (Trematoda: Digenea) lost all stage-specific traits?
Parasitol Res
January 2025
Department of Invertebrate Zoology, Saint Petersburg University, Universitetskaya emb., 7/9, Saint Petersburg, 199034, Russia.
Digeneans of the family Notocotylidae differ from other digeneans in their peculiar eggs. The eggs feature a pair of long filaments extending from their poles, and their contents differ significantly from what we expect to observe in the eggs of digeneans. Instead of a ciliated miracidium larva, the notocotylid egg contains a tiny few-celled mother sporocyst.
View Article and Find Full Text PDFLangerhans cell histiocytosis in children: the value of ultrasound in diagnosis and follow-up.
BMC Med Imaging
January 2025
Department of Ultrasound Medicine, First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Background: Langerhans cell histiocytosis (LCH) is a rare disease, most prevalent in children. Ultrasound is a noninvasive, cheap, and widely available technique. However, systematic elucidation of sonographic features of LCH and treatment related follow-up are relatively few, resulting in overall underestimation of the clinical value of ultrasound in diagnosing and monitoring LCH.
View Article and Find Full Text PDFHow Do the Valency and Radii of Cations Affect the Rheological Properties of Aqueous Solutions of Zwitterionic and Anionic Surfactant Mixtures?
Langmuir
January 2025
Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, ul. Berdychowo 4, PL 60-965 Poznan, Poland.
Despite extensive research on the use of salts to enhance micellar growth, numerous questions remain regarding the impact of ionic exchange and molecular structure on charge neutralization. This study looks into how certain cations (Na, Ca, and Mg) affect the structure of a cocamidopropyl betaine CAPB and sodium dodecylbenzenesulfonate SDBS surfactant mixture, aiming toward applications in targeted delivery systems. The mixture consists of a zwitterionic surfactant, cocamidopropyl betaine (CAPB), and an anionic surfactant, sodium dodecylbenzenesulfonate (SDBS), combined in varying molar ratios at a total concentration of 200 mM.
View Article and Find Full Text PDFEffect of Allium sativum, Thunbergia laurifolia, and Eurycoma longifolia crude extracts on the minute intestinal fluke, Haplorchis taichui.
Trop Biomed
December 2024
Parasitic Disease Research Center, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Haplorchis taichui is the minute intestinal fluke (MIF), presents a significant public health concern in Thailand. Despite praziquantel (PZQ) being the main treatment, concerns over recurrent use and drug resistance have surfaced. Thus, local herbal alternatives effective against gastrointestinal parasites could be crucial for reducing issues, necessitating exploration of herbal sources for alternative treatments.
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