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Venom composition, toxicity and cross-neutralization by PoliVal-ICP antivenom, of Mesoamerican jumping pitvipers genus Metlapilcoatlus (Viperidae: Crotalinae).
Trans R Soc Trop Med Hyg
January 2025
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica.
Background: The genus Metlapilcoatlus was recently erected to include six species of stout venomous snakes, known as the jumping pitvipers, which inhabit mountainous areas of Mesoamerica. This group maintains affinity with Atropoides picadoi, another jumping pitviper with restricted distribution in Costa Rica and Panama. Although the venom of A.
View Article and Find Full Text PDFAbility of brazilian Bothrops-Lachesis-Crotalus antivenom in neutralizing some biological activities of Crotalus durissus ruruima rattlesnake venom.
Toxicon
January 2025
Teaching and Research Center, Francisca Mendes Heart Hospital Foundation, Manaus, 69097-720, Brazil; Research management, Hospital Foundation of Hematology and Hemotherapy of Amazonas, 69050-001, Brazil. Electronic address:
We evaluated the efficacy of freeze-dried Bothrops-Lachesis-Crotalus antivenom and liquid Crotalus antivenoms to neutralize Crotalus durissus ruruima (Cdr) venom (Roraima, Brazil) comparing with C. d. terrificus (Cdt) venom.
View Article and Find Full Text PDFThe Protective Action of (Rubiaceae) on the Neuromuscular Blockade Induced by (Viperidae: Crotalinae) Venom.
Biomed Res Int
November 2024
Graduate Program in Pharmaceutical Sciences, University of Sorocaba (UNISO), Sorocaba, São Paulo, Brazil.
Article Synopsis
- * Biological tests demonstrated that the extract can reduce venom-induced neuromuscular blockade when applied before exposure, but not after, suggesting timing is crucial for effectiveness.
- * While quinine was not found in the extract, the presence of coumarin derivatives and other unknown alkaloids may contribute to the extract's ability to mitigate the effects of the venom.
A genus-wide study on venom proteome variation and phospholipase A inhibition in Asian lance-headed pit vipers (genus: Trimeresurus).
Comp Biochem Physiol C Toxicol Pharmacol
February 2025
Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; School of Medicine, College of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, Taiwan; Institute of Bioinformatics and Structural Biology, College of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
Article Synopsis
- The research utilized techniques like SDS-PAGE and LCMS/MS to investigate venom protein variability and identified conserved protein families with diverse expressions that do not follow snake evolutionary lineages.
- Key findings indicate that while certain enzymes' expression correlates weakly with venom effects, phospholipase A activity strongly correlates with its abundance, and a small molecule inhibitor, varespladib, may effectively inhibit PLA activities, suggesting its potential as a therapeutic for snakebite treatment.
A simple method to determine proteolytic activity of snake venoms.
Toxicon
November 2024
Laboratorio de Toxinopatología, Departamento de Patología, Facultad de Medicina, José E. Uriburu 950, 5(to) piso (1114), Universidad de Buenos Aires, Buenos Aires, Argentina; Instituto Nacional de Producción de Biológicos I.N.P.B. - A.N.L.I.S. ''Dr. Carlos G. Malbrán'', Ministerio de Salud, Av. Vélez Sarsfield 563 (1282), Buenos Aires, Argentina; Área Investigación y Desarrollo - Venenos, Aracnario-Serpentario. Instituto Nacional de Producción de Biológicos, A.N.L.I.S. "Dr. Carlos G. Malbrán", Av. Velez Sarsfield 563 (1282). Buenos Aires, Argentina. Electronic address:
In this work, we describe an easy, simple, and cost-effective method to assess the proteolytic activity of snake venoms. The method is based on measuring the hydrolytic halo formed by gelatin radial hydrolysis following the incubation of venoms on a solid gelatin-agarose plate. Venoms from Bothrops (B.
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