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Studies have been made of the effect of hydrocortisone on the rate of the increase in the body mass and on the rate of linear growth of rats in different age periods. Retardation of physical development of animals is most significant in all the three weanling periods and in a pre-pubertal one. After abolition of hydrocortisone in all the three weanling periods and in a pre-pubertal one. After abolition of hydrocortisone injections, compensatory growth was noted in rats, which was most significant in animals pretreated by the hormone at earlier postnatal periods. Retardation in the body mass disappears to the period of sexual maturation, whereas retardation in the linear growth persists for a longer time.

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