[Disturbanes in electrostatic balance of erythrocyte membranes in experimental D-hypovitaminosis].

Violation of electrostatic balance in the erythrocyte membranes with experimental D-hypovitaminosis is determined by the method of potentiometric titration. It is pronounced in modification of quantity and pK of accessible polar groups and in a decrease in total membrane electronegative charge. This violation is supposed to be provoked by a considerable increase in cholesterol content in the membranes and to reflect a modification in the character and bond strength of protein lipid complexes caused by interaction of cholesterol with membrane components. The role of the membrane components polar groups in binding an additional quantity cholesterol and decreasing in permeability of erythrocyte membranes under conditions of D-hypovitaminosis are discussed.