Two biologically active peptides designated SCP-1 and SCP-2 have been isolated and partially characterized from porcine spinal cord. The results of amino acid analysis, electrophoresis, isoelectric focusing and the chromatographic analysis of the dansylated derivatives indicate that these two peptides are homogeneous. The amino acid composition and apparent untriakontapeptide and SCP-2 is a pentacospeptide. The N-terminal amino acids of SCP-1 and SCP-2 are Arginine and Tryptophan respectively. SCP-1 can stimulate the contraction of isolated guinea pig ileum and SCP-2 induces hypotension in anesthetized rat. Both SCP-1 and SCP-2 show no morphine-like activity. The chemical composition and biological properties of SCP-1 and SCP-2 distinguish them from any known peptide.
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