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Background: Traditional liver fibrosis staging via percutaneous biopsy suffers from sampling bias and variable inter-pathologist agreement, highlighting the need for more objective techniques. Deep learning models for disease staging from medical images have shown potential to decrease diagnostic variability, with recent weakly supervised learning strategies showing promising results even with limited manual annotation.

Purpose: To study the clustering-constrained attention multiple instance learning (CLAM) approach for staging liver fibrosis on trichrome whole slide images (WSIs) of children and young adults.

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Objective: This study was aimed at investigating the roles of podoplanin (PDPN) as a marker associated with malignant development, progression, and poor prognosis in oral leukoplakia and various forms of oral squamous cell carcinoma (OSCC), particularly in relation to the extent of invasion.

Methods: Immunohistochemical analysis of PDPN was conducted on 77 histologically confirmed, formalin-fixed, paraffin-embedded samples representing various degrees of OSCC invasion and dysplasia grades.

Results: The samples were analyzed with Fisher's exact test and the Kruskal-Wallis test.

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Proposal of staging system and treatment guideline for diagnostically challenging primary intra-osseous carcinoma: A retrospective single-center case series and literature review.

J Stomatol Oral Maxillofac Surg

January 2025

Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul National University Dental Hospital, Seoul, 03080, South Korea; Department of One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, South Korea. Electronic address:

The objective of this retrospective study is to examine the clinical, imaging and pathologic features of 10 patients diagnosed with 'primary intraosseous carcinoma (PIOC)' at a single institution and to identify factors affecting the prognosis of PIOC patients. By proposing a new staging system based on tumor size, cortical bone deformation, neck metastasis and histologic grade, the study aims to address the lack of a distinct staging system, which has led to the mixed use of oral squamous cell carcinoma classification. Furthermore, the study intends to propose a treatment guideline based on the newly proposed staging system.

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Mares with endometrosis exhibit histological changes not only in the endometrium but also in the myometrium that suggest possible functional impairment. The molecular background of these changes is not well understood. We hypothesize that the transcriptomic profile of the mare myometrium varies depending on the degree of endometrosis in mares.

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A rare case of recurrent calcifying epithelial odontogenic tumor in an adolescent patient: Case report and review of literature.

Oral Oncol

January 2025

Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun 130012, China. Electronic address:

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic epithelial tumor characterized by the presence of amyloid material within the tumor that can undergo calcification. CEOT affects individuals across a broad age range, typically between 20 and 60 years, with an average onset age of 40 years. However, it is extremely rare in children and adolescents.

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