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Trojan Horse Bioheterojunction Empowers Adhesive Hydrogel with Robust Antibacterial Activity and Sensing Capacity for Infected Cutaneous Regeneration.
Nano Lett
December 2024
West China Hospital of Stomatology, School of Chemical Engineering, Sichuan University, Chengdu 610041, China.
Strategic integration of adhesive hydrogels with phototherapy-based antibacterial properties has been extensively leveraged in infected tissue repair. Nevertheless, the interference of bacterial heat shock proteins and antioxidant defense systems attenuates the bactericidal potency of phototherapy. To address this imposing predicament, a Trojan horse bioheterojunction (Th-bioHJ) incorporating liquid metal and copper sulfide is devised to confer an adhesive hydrogel with multimodal and comprehensive antibacterial properties for remedying infectious wounds.
View Article and Find Full Text PDFBeneficial effects of pentoxifylline on spermatogenesis and germ cell apoptosis in stallions subjected to scrotal heat stress.
Theriogenology
February 2025
Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, UK, Lexington, KY, USA.
This study evaluated the effects of oral pentoxifylline on testicular biometry, histology, and gene expression in stallions subjected to scrotal heat stress. Fourteen stallions were divided into three groups: Control (CRL, n = 4), Testicular Degeneration (DEG, n = 5), and Testicular Degeneration Treated with Pentoxifylline (DEG + PTX, n = 5). Testicular degeneration was induced by scrotal insulation, twice daily, over two consecutive days (D-1 and D0).
View Article and Find Full Text PDFGenetic diversity and phylogenetic relationships of Theileria equi inferred from heat shock protein 70 kDa gene sequences in Brazilian horses.
Vet Res Commun
November 2024
Department of Epidemiology and Public Health, Federal Rural University of Rio de Janeiro (UFRRJ), BR 465, Km 7, Seropedica, 23890000, RJ, Brazil.
Article Synopsis
- Equine piroplasmosis, a disease caused by Babesia and Theileria parasites transmitted by ticks, poses significant clinical and economic threats globally, particularly to horses.
- This research focused on analyzing the heat shock protein 70 kDa (hsp70) gene sequences of Theileria equi from infected horses in Brazil, using methods like PCR and phylogenetic analysis to explore genetic relationships among parasites.
- Findings revealed two distinct genotypes of T. equi in Brazil, with hsp70 proving to be an effective molecular marker for distinguishing between closely related species and offering insights into the evolutionary history of these parasites.
Walter Brendel and the dawn of transplantation research in Germany.
Front Transplant
September 2024
German Academy for Transplantation Medicine, Munich, Germany.
Walter Brendel was a physiologist who headed the Institut of Experimental Surgery at the University of Munich (LMU) from 1961 until 1989. His legendary career began with the development of an anti-human lymphocyte globulin (ALG) at his Institute during the late 1960s. The initial successful treatment of a small number of patients culminated in the co-treatment of the first successfully heart-transplanted patient in Capetown, South Africa (successful reversal with ALG of an acute allograft rejection).
View Article and Find Full Text PDFImaging Identifies Superior Inflammation Targeting of M1 Macrophages for Cryo-Shocked Cell Pulmonary Drug Delivery to Treat Acute Lung Injury.
Adv Healthc Mater
December 2024
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, P. R. China.
In the realm of combating acute lung injury (ALI) induced by a myriad of triggers including sepsis, pneumonia, aspiration, trauma, and pancreatitis, macrophages emerge as crucial players. However, traditional treatments such as systemic administration of glucocorticoids come with the baggage of severe side effects, curtailing their utility. Enter an innovative solution: a biomimetic drug delivery system fashioned from cryo-shocked macrophages, tailored for pulmonary drug delivery.
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