A case of primary duodenal adenocarcinoma is described. A discussion is made about the rarity of this tumor that, as it is frequency misdiagnosed in cases of malignant neoplasms of the papilla of Vater and of terminal part of the common biliary duct, may be greater than all previously thought. Tumors of the third part of duodenum are even more uncommon. Whipple resection seem the best cure of this tumors, as results from long term survival.
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