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Objective: To investigate the role that foot-strike hemolysis plays in sports-related anemia in marathon and ultramarathon runners.
Data Sources: PubMed, Embase, Cochrane, Grey literature.
Study Selection: Inclusion criteria consisted of human studies with runners completing a sanctioned race of marathon distance or greater, with outcomes measured by pre- and post-race hematological assessments.
Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving.
J Dairy Sci
February 2025
Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602. Electronic address:
Article Synopsis
- This study examined inflammation and immune cell changes in the mammary glands of Holstein dairy cows transitioning between late lactation and the dry period, and from the dry period to early lactation.
- Healthy cows showed increased systemic inflammatory markers like TNF-α and haptoglobin after dry-off, along with changes in milk composition.
- Cell proliferation rates in mammary tissue were higher after dry-off, with specific immune cell populations varying between the late dry and early lactation stages.
Changes in immuno-inflammatory and antioxidant biomarkers in serum and cerebrospinal fluid of dogs with distemper.
Microb Pathog
January 2025
Department of Internal Medicine, Faculty of Veterinary Medicine, Bursa Uludag University, 16059, Bursa, Turkey.
Article Synopsis
- Canine distemper virus (CDV) leads to serious health issues in dogs, particularly affecting the central nervous system, but little is known about how certain biomarkers relate to the disease.
- The study aimed to compare serum biomarkers between 10 dogs infected with CDV and 10 healthy dogs and to analyze correlations between serum and cerebrospinal fluid (CSF) biomarkers.
- Results showed that certain inflammatory cytokines and antioxidant levels were significantly higher in dogs with CDV, and specific cytokines in CSF were correlated with those in serum, suggesting these could assist in diagnosing neurological involvement in CDV infections.
Top-Down Proteomics Identifies Plasma Proteoform Signatures of Liver Cirrhosis Progression.
Mol Cell Proteomics
December 2024
Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address:
Article Synopsis
- - Cirrhosis affects 2 to 5 million Americans, with most patients experiencing compensated cirrhosis, yet many can develop serious complications that severely shorten life expectancy.
- - Identifying high-risk patients with compensated cirrhosis is crucial for improving their care and directing them to specialty treatment, as not all patients receive this level of care.
- - This pilot study identified 209 differentially expressed proteoforms in the plasma of cirrhosis patients at various stages, highlighting potential biomarkers that could help in early diagnosis and risk assessment.
Dietary supplementation with citrus peel extract in transition period improves rumen microbial composition and ameliorates energy metabolism and lactation performance of dairy cows.
J Anim Sci Biotechnol
November 2024
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Article Synopsis
- The study explored how citrus peel extract (CPE) affects the rumen microbiota, energy metabolism, and milk production in dairy cows during the transition period around calving.
- Dairy cows were divided into two groups: one received a standard diet while the other was given CPE for 6 weeks, with various samples collected to assess the impacts.
- Results showed that CPE supplementation improved milk yield and quality, increased serum glucose levels, altered rumen microbial composition, decreased harmful metabolites, and enhanced insulin sensitivity in both adipose tissue and liver.
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