222Rn Determination method by liquid scintillation counter after extracting 222Rn with p-xylene was studied. It was confirmed that extraction of 222Rn with p-xylene proceeds quantitatively. Several experimental conditions for the counting such as scintillator content in p-xylene, the quencher effect, the zero level extrapolation method and 3-channel counting method were examined. The recommended procedures were successfully applied to measure 222Rn content in one of the natural water. It was noticed that we should pay attention to 220Rn (Tn) which is simultaneously extracted with 222Rn in case of p-xylene extraction.
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http://dx.doi.org/10.3769/radioisotopes.27.9_504 | DOI Listing |
Anal Chim Acta
February 2025
Department of Chemistry and Applied Biosciences, Laboratory of Inorganic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, Zürich, CH-8093, Switzerland; Laboratory of Radiochemistry, Centre for Nuclear Engineering and Sciences, Paul Scherrer Institute, Forschungsstrasse 111, Villigen PSI, CH-5232, Switzerland. Electronic address:
Background: The direct and accurate measurement of low-level γ-emitters in samples from nuclear facilities is a challenging task due to the presence of high activities of dominant radionuclides. In this case a complex chemical separation is required to remove interfering radionuclides prior to γ-spectrometric analysis. Several radionuclides such as, Ag, Sb, Sn and Te are of relevance for radioanalytical analysis in nuclear facilities.
View Article and Find Full Text PDFNeuropeptides
January 2025
Department of Pathophysiology, Faculty of Medicine, University of Szeged, Hungary.
Corticotropin-releasing factor (CRF) and urocortins (UCN1, UCN2 and UCN3) belong to the same CRF family of neuropeptides. They regulate the neuroendocrine, autonomic and behavioral responses to stress via two CRF receptors (CRF1 and CRF2). Stress, anxiety and depression affects the activity of the hypothalamic-pituitary-adrenal (HPA) axis and the serotoninergic neurotransmission, both being regulated by CRF and CRF-related peptides.
View Article and Find Full Text PDFInt J Pharm
January 2025
Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China. Electronic address:
Amyotrophic lateral sclerosis (ALS) presents a substantial challenge due to its complex nature, limited effective treatment options, and modest benefits from current therapies in slowing disease progression. This study explores the potential of intranasal (IN) delivery to enhance the CNS delivery of riluzole (RLZ), a standard ALS treatment which is subject to blood-brain barrier efflux mechanisms. Additionally, the impact of elacridar (ELC), an efflux pump inhibitor, on IN RLZ CNS bioavailability was examined.
View Article and Find Full Text PDFAppl Radiat Isot
January 2025
China University of Geosciences, Beijing, 100084, China.
The accuracy of measuring the activity of Lu is crucial for calibrating the instruments employed in clinical applications. To support the measurements of Lu solution, the existing TDCR-Čerenkov method has been extended for this nuclide. The contribution of β and γ transitions from Lu was taken into account in the extended method.
View Article and Find Full Text PDFPLoS One
January 2025
Research Center for Chemical Information and Management, National Institute of Occupational Safety and Health, Kawasaki, Japan.
A potential link has been reported between skin exposure to aromatic amines, such as ortho-toluidine (OT) and 3,3'-dichloro-4,4'-diaminodiphenylmethane (MOCA), and bladder cancer cases observed in Japanese chemical factories. To evaluate this association, we explored the permeability of OT and MOCA through pig skin and investigated the subsequent changes in plasma and urine concentrations in rats following percutaneous exposure. Employing Yucatan micropig skin, we first executed a permeability test by affixing the skin to a diffusion cell and applying 14C-labeled OT or MOCA.
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