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Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation.
Heliyon
January 2025
Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA.
Background: There is higher prevalence of chronic kidney disease (CKD) in burn patients after hospital discharge; however, the cause remains unclear. This study aimed to investigate the lasting impacts of severe burns on the kidneys and to explore potential treatments.
Methods: The study examined the effects of burning on healthy mice and adenine-induced CKD mice.
Persistent Menorrhagia and Hemorrhagic Ovarian Cyst in a Patient With Bernard-Soulier Syndrome: A Case Report.
Cureus
December 2024
Hematology, Dubai Hospital, Dubai Health, Dubai, ARE.
Bernard-Soulier syndrome (BSS) is a rare qualitative condition of platelets wherein deficiency of platelet surface glycoproteins (GP) Ib, IX, and V forms the Ib-IX-V complex, leading to impaired hemostasis. Although it commonly presents as prolonged bleeding in general, women in the reproductive phase report additional complications during menstruation, pregnancy, and childbirth. In women of reproductive age, menorrhagia is a frequent complaint.
View Article and Find Full Text PDFWhat Is the Clinical Value of Long Head of Biceps Tendon Tests in Distal Supraspinatus Tendon Rupture? A Prospective Multicenter Study.
J Shoulder Elbow Surg
January 2025
Université de Tours - Faculté de Médecine de Tours - CHRU Tours, Hôpital Trousseau, Service d'Orthopédie Traumatologie, Tours, France. Electronic address:
Purpose: The purpose of this study was to determine the clinical value of diagnostic tests for the long head of the biceps tendon (LHBT) injuries in the setting of a Patte stage 1 supraspinatus tendon rupture.
Methods: This was a prospective cohort multicenter study of 361 patients aged 30 to 80 years with Patte stage 1 distal supraspinatus tendon rupture. The LHBT was assessed clinically by palpation of the bicipital groove, the speed test, the Yergason test and the Kibler test.
Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An biomechanical study.
Front Bioeng Biotechnol
January 2025
Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical Universit, Guangzhou, China.
Objective: The aim of this study is to assess the kinematic changes in the knee joint during walking in patients with isolated PCL-deficiency (PCLD) to determine the presence of walking-related joint instability (mechanical instability-abnormal displacement form structural damage). Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.
Methods: 35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study.
Coronin1A regulates the trafficking of alpha synuclein in microglia.
J Neurosci
January 2025
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03766, USA.
Microglia respond to cytotoxic protein aggregates associated with the progression of neurodegenerative disease. Pathological protein aggregates activate the microglial NLRP3 inflammasome resulting in proinflammatory signaling, secretion, and potentially pyroptotic cell death. We characterized mixed sex primary mouse microglia exposed to microbial stressors and alpha synuclein preformed fibrils (αsyn PFFs) to identify cellular mechanisms related to Parkinson's disease.
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