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Repurposing radiosensitising medicines for radiotherapy: an overview.
BMJ Oncol
January 2024
Department of Oncology, University of Oxford, Oxford, UK.
Repurposing established non-cancer drugs for the treatment of cancer offers potential benefits such as speed of clinical translation and financial efficiencies. In this study, we assess the landscape of repurposing drugs for combined use with radiotherapy (RT) based on their capacity to increase tumour radiosensitivity. Using a literature-based approach, we identified 42 radiosensitising drugs with varied non-cancer indications and mechanisms of action, that have entered or completed clinical trials in combination with RT or with chemoradiotherapy.
View Article and Find Full Text PDFKidney Biopsy-Proven Diabetic and Non-Diabetic Kidney Diseases and Outcomes in Patients With Type 2 Diabetes Receiving Dialysis: The REIN Registry.
Kidney Med
February 2025
AURAL Strasbourg, Renal Research Division, 5 rue Henri Bergson, 67200 Strasbourg, France.
Rationale & Objective: Chronic kidney disease (CKD) in patients with diabetes does not always equate to diabetic kidney disease (DKD). This study aims to delineate and compare the clinical characteristics, survival rates, and access to kidney transplantation among patients with type 2 diabetes commencing dialysis, who were classified by kidney biopsy as having either DKD or non-diabetic kidney disease (non-DKD).
Study Design: We used the comprehensive French Renal Epidemiology and Information Network registry to analyze baseline clinical characteristics at dialysis inception and outcomes defined as death and access to kidney transplantation.
Indications for and limitations of laparoscopic anatomical liver resection: assessment of postoperative complications stratified by complexity of liver resection.
Surg Endosc
January 2025
Department of Hepato-Biliary-Pancreatic Surgery, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima-Ku, Osaka, 534-0021, Japan.
Background: Although complex anatomical liver resections are more often being performed laparoscopically, the short-term outcomes following laparoscopic anatomical liver resection (LALR), its optimal indications, and limitations remain unclear. This study aimed to clarify the indications for and limitations of LALR by assessing the short-term outcomes.
Methods: This retrospective study included 233 patients who underwent LALR.
[Direct Surgery for Spinal Arteriovenous Shunt Disease: Indication and Technical Tips].
No Shinkei Geka
January 2025
Department of Neurological Surgery, Okayama University Graduate School of Medicine.
Spinal arteriovenous(AV) shunt disease is rare, although many neurosurgeons may encounter patients with the disease. Recently, the pathological findings and classification of spinal AV shunt disease have been well described. The fundamental treatment of spinal AV shunt disease involves interruption of the shunt, which is achieved by endovascular treatment or direct surgery.
View Article and Find Full Text PDF[Anterior Cervical Decompression and Fusion:Surgical Concept of Anterior Decompression and Selection of Internal Fixation Devices].
No Shinkei Geka
January 2025
Department of Spinal Surgery, Akita Cerebrospinal and Cardiovascular Center.
Anterior cervical fixation is an excellent surgical technique for the removal of anterior compressive elements affecting the spinal cord and nerve roots while addressing cervical instability. However, it is important to recognize the unique challenges posed by the proximity of critical structures, including the trachea, esophagus, carotid sheath, and recurrent laryngeal nerve. Access to the upper cervical spine is often limited to the mandible.
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