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Artificial Lipidation of Antifungal Proteins and Antifungal Behavior: A Case Study with Cholesterylation.
Chembiochem
March 2025
Kyushu University: Kyushu Daigaku, Applied Chemistry, 744 Motooka, Nishi-ku, 819-0395, Fukuoka, JAPAN.
Lipid-based formulation of antifungal small drugs is used to mitigate drug toxicity while retaining effective antifungal activity. Our previous work demonstrated a method to enhance the antifungal properties of a chitin-binding domain (LysM) and catalytic domain (CatD) of antifungal chitinase by microbial transglutaminase (MTG)-mediated palmitoylation. Herein, we studied the effect of artificial cholesterylation of LysM and CatD, both of which were site-specifically modified using an MTG-catalyzed crosslinking.
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Department of Biophysics, School of Medicine, Koç University, Sarıyer, Istanbul, Türkiye.
In this study, the cytotoxic effects of pexidartinib (PLX), a tyrosine kinase inhibitor approved for tenosynovial giant cell tumor through inhibition of colony-stimulating factor 1 receptor (CSF1R), against A549 lung adenocarcinoma cells and Beas-2B healthy bronchial cells were investigated by in detailed in-vitro and in-silico studies. Through MTT assays, PLX demonstrated significant inhibition of A549 cell viability with IC values of 2.15 and 1.
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Front Cardiovasc Med
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Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Giant cell myocarditis is a rare and rapidly progressive disease with a high mortality rate. We present the case of a 21-year-old male without a medical history who presented with a giant left ventricle (9.9 cm, EF:10%) and in a severe clinical state.
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Am J Surg Pathol
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Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Giant cell tumors of bone are locally aggressive, frequently harbor H3F3A p.G34W mutations, and rarely undergo malignant transformation. The pathogenesis of malignant transformation remains incompletely characterized.
View Article and Find Full Text PDFFunctional Characterization of , , and in Cucumber Defense Against .
Int J Mol Sci
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Beijing Key Laboratory of Growth and Development Regulation for Protected Vegetable Crops, College of Horticulture, China Agriculture University, Beijing 100193, China.
Vascular tissue development plays a pivotal role in plant growth and defense against biotic stress. Root-knot nematodes, particularly (), are globally distributed phytopathogens that cause severe economic losses in a variety of vascular plants. In this study, three vascular bundle development-related genes, including , , and , were identified in cucumber.
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