Carcinoembryonic antigen (CEA), an oncofetal glycoprotein, has been originally suggested as a tumor marker for colorectal cancer and afterwards has been regarded as a specific marker for different cancers. The determination of CEA in 73 patients with "benign" hepatic diseases points out the limitation of test's diagnostic value on account of the not infrequent observation of false positives in the examined cases. In particular the greatest incidence and intensity of elevated levels of CEA has been found in hepatic cirrhosis. However must be mentioned that the highest values of CEA has been documented nearly constantly in the comparison's group of some forms of malignancies, between which nevertheless there have been sporadically false negatives.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Label-free electrochemical immunosensors based on Cu-Ni metal-organic framework and carbon nanotube composite for carcinoembryonic antigen detection.
Bioelectrochemistry
January 2025
Hubei Key Laboratory of Diabetes and Angiopathy, Xianning 437100 PR China; School of Pharmacy, Hubei University of Science and Technology, Xianning 437100 PR China. Electronic address:
Monitoring cancer biomarkers is of great significance in clinical diagnosis. In this work, a label-free MWCNTs-COOH/CuNi-BTC/FTO electrochemical immunosensor was developed to quantitatively detect carcinoembryonic antigen (CEA). The bimetallic CuNi-BTC showed enhanced current than singe Ni-BTC, and the addition of the MWCNTs-COOH increased the conductivity and further amplified the current signal.
View Article and Find Full Text PDFPrognostic Impact of the Postoperative Carcinoembryonic Antigen Level after Curative Resection of Locally Advanced Rectal Cancer.
J Anus Rectum Colon
January 2025
Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Objectives: This study was conducted to investigate whether preoperative or postoperative carcinoembryonic antigen (CEA) with a new cut-off value is more optimal for predicting long-term outcomes in patients with Stage II/III rectal cancer, and to investigate the effectiveness of postoperative adjuvant chemotherapy (POAC) based on the CEA values.
Methods: Serum CEA levels were measured preoperatively (pre-CEA) and postoperatively (post-CEA). The area under the receiver operating curve (AUROC) was used to determine a cut-off for CEA.
Postoperative Surveillance Adherence in Colorectal Cancer Patients at Urban Medical Centers: Is It Adequate?
Cureus
December 2024
General Surgery, Corewell Health Dearborn Hospital, Dearborn, USA.
Introduction Colorectal cancer (CRC) is among the most frequent cancers in the United States. There are recognized guidelines for monitoring after curative CRC excision. This study looks into the rate of compliance with surveillance guidelines following CRC resection, as well as the impact of demographic characteristics.
View Article and Find Full Text PDFUltrasensitive and selective impedance paper-based analytical device through Dual-C imprinted sensor for determination of carcinoembryonic antigen and C-reactive protein.
Mikrochim Acta
January 2025
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
Carcinoembryonic antigen (CEA) and C-reactive protein (CRP) are biomacromolecules known as cancer and inflammatory markers. Thus, they play a crucial role in early cancer diagnosis, post-treatment recurrence detection, and tumor risk assessment. This paper describes the development of an ultrasensitive and selective imprinted paper-based analytical device (PAD) as impedance sensor for determination of CEA and CRP in serum samples for point-of-care testing (POCT).
View Article and Find Full Text PDFF-18 FDG PET/CT based Preoperative Machine Learning Prediction Models for Evaluating Regional Lymph Node Metastasis Status of Patients with Colon Cancer.
Asian Pac J Cancer Prev
January 2025
Department of Nuclear Medicine, Busan Paik Hospital, University of Inje College of Medicine, Busan, Republic of Korea.
Objective: This study aimed to develop a simple machine-learning model incorporating lymph node metastasis status with F-18 Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and clinical information for predicting regional lymph node metastasis in patients with colon cancer.
Methods: This retrospective study included 193 patients diagnosed with colon cancer between January 2014 and December 2017. All patients underwent F-18 FDG PET/CT and blood test before surgery.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!