The effects of bromocriptine and perphenazine on C3H/HeJ mouse seminal vesicles were studied. The response of the stroma and parenchyma of the glands to the hormones differed. Testosterone repressed stromal proliferation. Prolactin had no observable stromal effect but influenced the response of the parenchyma. In castrated mice, low levels of prolactin were associated with abnormal epithelial mitotic activity and atypical cytology while elevated prolactin levels resulted in a nonatrophic epithelium similar to that from the seminal vesicles of intact individuals. In the absence of testicular testosterone, prolactin may exert an inhibitory influence on glandular proliferation.
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