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Associations of macrosomia with sociodemographic, anthropometric, lifestyle factors and perinatal outcomes in Southwest Nigeria.
BMC Pediatr
January 2025
Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Background: Currently, macrosomia contributes to maternal and neonatal morbidity and mortality in low-and middle-income countries because of changes in maternal lifestyle. Reliable data are needed for its prevention, early detection, and management. This study assessed the associations between sociodemographic, anthropometric, maternal lifestyle, perinatal outcomes, and macrosomia in Southwest Nigeria.
View Article and Find Full Text PDFPontine Osmotic Demyelination Syndrome in a Pregnant Woman With Sepsis and Wernicke's Encephalopathy.
Cureus
November 2024
Internal Medicine, Dubai Medical College for Girls, Dubai, ARE.
A pregnant woman was brought to the emergency department looking starved and neglected. She was diagnosed with sepsis and started on intravenous antibiotics. She was also disoriented and hypernatremic.
View Article and Find Full Text PDFPatterns of Medication for Opioid Use Disorder During Pregnancy, 7 Clinical Sites, MATernaL and Infant clinical NetworK (MAT-LINK), 2014-2021.
J Addict Med
December 2024
From the Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA (ELT, AND, KM, SMG, LG, DMM-D, SYK); Eagle Global Scientific, Atlanta, GA (ELT, AND); G2S Corporation, Shavano Park, Texas (AND); Department of Epidemiology, Emory University, Atlanta, GA (AND); Friends Research Institute, Baltimore, MD (MT); University of New Mexico Health Sciences Center, Albuquerque, NM (PMS, LL); University of Rochester, Rochester, NY (NSS, SC); University of South Florida, Tampa, FL (TW, JML); Boston Medical Center, Boston, MA (EMW, HS); University of Utah, Salt Lake City, UT (MS, JS); Center for Health Research, Kaiser Permanente Northwest, Portland, OR (MH, AD); and The Ohio State University, Columbus, OH (PDS, KR).
Article Synopsis
- The study analyzed medication patterns for opioid use disorder (MOUDs) during pregnancies among a cohort of 3,911 expectant mothers with opioid use disorder (OUD) from seven clinical sites.
- It found that over 90% of pregnancies involving methadone were among publicly insured individuals, and there was an increasing usage of buprenorphine with naloxone and naltrexone in recent years.
- The research highlighted that most prenatal care and MOUD documentation occurred within the same trimester, but discontinuity in MOUD treatments across trimesters still existed, indicating a need for improved access to care during pregnancy.
Neuroimmune Characteristics of Animals with Prenatal Alcohol Intoxication.
Biochemistry (Mosc)
November 2024
Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, 119002, Russia.
Neuroinflammation can be an important factor of many disorders in central nervous system (CNS) including cognitive dysfunction, affective disorders, and addictive behavior associated with prenatal alcohol exposure and presented in early adulthood. In this study we used an experimental rodent model of prenatal alcohol (PA) exposure (consumption of a 10% ethanol solution by female Wistar rats throughout pregnancy), multiplex immunofluorescence analysis of interleukins (IL-1α, IL-1β, IL-3, IL-6, IL-9, and IL-12), tumor necrosis factor (TNF-α), and chemokine CCL5, as well as quantitative real-time PCR to assess the level of cytokine mRNAs in the prefrontal cortex of the sexually mature (PND60) offspring - male and female rats with prenatal alcohol intoxication and control animals. Significant decrease in the content of TNF-α and interleukins IL-1β, IL-3, IL-6, IL-9 was detected in the prefrontal cortex of male, but not in the female PA offspring.
View Article and Find Full Text PDFDifferential effects of prenatal alcohol exposure on brain growth reveals early upregulation of cell cycle and apoptosis and delayed downregulation of metabolism in affected offspring.
PLoS One
November 2024
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America.
Article Synopsis
- Fetal Alcohol Spectrum Disorder (FASD) results from prenatal alcohol exposure (PAE) and can lead to a range of developmental issues, such as delays and cognitive difficulties, influenced by various factors including timing and genetics.
- This study investigated how PAE during early mouse development affected brain growth and gene expression, revealing differences in brain weight among offspring even from the same genetic background.
- Key findings indicated that while normal-weight brains showed no changes in gene expression, both middle- and low-weight brains exhibited significant molecular differences, along with distinct responses to PAE over time.
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