A simplified approach to coagulum pyelolithotomy, utilizing ureteral catheters for injection of the coagulum, is advantageous for small intrarenal pelves, or when it is difficult to mobilize the kidney because of a previous operation. The approach is technically easy and straight-forward. We highly recommend its use in selected cases.
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http://dx.doi.org/10.1016/0090-4295(81)90068-6 | DOI Listing |
Metabolites
January 2025
Department of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Blood microsampling (BμS) has recently emerged as an interesting approach in the analysis of endogenous metabolites but also in metabolomics applications. Their non-invasive way of use and the simplified logistics that they offer renders these technologies highly attractive in large-scale studies, especially the novel quantitative microsampling approaches such as VAMs or qDBS. Herein, we investigate the potential of BµS devices compared to the conventional plasma samples used in global untargeted mass spectrometry-based metabolomics of blood.
View Article and Find Full Text PDFJ Pers Med
January 2025
Stroke Unit, Department of Neurology, University of Pécs, 7624 Pécs, Hungary.
: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Despite advances in interventions such as thrombolysis (TL) and mechanical thrombectomy (MT), current treatment protocols remain largely standardized, focusing on general eligibility rather than individual patient characteristics. To address this gap, we introduce the Stroke-SCORE (Simplified Clinical Outcome Risk Evaluation), a predictive tool designed to personalize AIS management by providing data-driven, individualized recommendations to optimize treatment strategies and improve patient outcomes.
View Article and Find Full Text PDFCurr Issues Mol Biol
December 2024
Department of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA 71103, USA.
Tacrolimus and mycophenolate are important immunosuppressive agents used to prevent organ rejection in post-transplant patients. While highly effective, their use is associated with significant toxicity, requiring careful management. Tacrolimus, a calcineurin inhibitor, is linked to nephrotoxicity, neurotoxicity, metabolic disturbances such as diabetes mellitus and dyslipidemia, and cardiovascular complications such as hypertension and arrhythmias.
View Article and Find Full Text PDFEntropy (Basel)
January 2025
Instituto Universitario de Investigacion en Ingenieria de Aragon (I3A), Universidad de Zaragoza, 50018 Zaragoza, Spain.
Optimizing complex systems usually involves costly and time-consuming experiments, where selecting the experiments to perform is fundamental. Bayesian optimization (BO) has proved to be a suitable optimization method in these situations thanks to its sample efficiency and principled way of learning from previous data, but it typically requires that experiments are sequentially performed. Fully distributed BO addresses the need for efficient parallel and asynchronous active search, especially where traditional centralized BO faces limitations concerning privacy in federated learning and resource utilization in high-performance computing settings.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
Department of Electronic Computational Equipment Design, National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", 03056 Kyiv, Ukraine.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and neuropsychiatric symptoms resulting from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). Dopamine transporter scan (DATSCAN), based on single-photon emission computed tomography (SPECT), is commonly used to evaluate the loss of dopaminergic neurons in the striatum. This study aims to identify a biomarker from DATSCAN images and develop a machine learning (ML) algorithm for PD diagnosis.
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