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Intermittent prophylactic antibiotics for bronchiectasis.

Cochrane Database Syst Rev

January 2022

Medical School, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, UK.

Background: Bronchiectasis is a common but under-diagnosed chronic disorder characterised by permanent dilation of the airways arising from a cycle of recurrent infection and inflammation. Symptoms including chronic, persistent cough and productive phlegm are a significant burden for people with bronchiectasis, and the main aim of treatment is to reduce exacerbation frequency and improve quality of life. Prophylactic antibiotic therapy aims to break this infection cycle and is recommended by clinical guidelines for adults with three or more exacerbations a year, based on limited evidence.

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Background: The aim of this meta-analysis was to evaluate the diagnostic value of lung ultrasound (LUS) in comparison to chest radiography (CXR) in children with pneumonia.

Methods: Computer-based retrieval was performed on PubMed and EMBASE. Quality was evaluated according to the quality assessment of diagnostic accuracy studies-2, and Meta-Disc was adopted to perform meta-analysis.

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Head-to-head trials of antibiotics for bronchiectasis.

Cochrane Database Syst Rev

September 2018

EPRC, Faculty of Health and Social Care, Edge Hill University, Ormskirk, UK.

Background: The diagnosis of bronchiectasis is defined by abnormal dilation of the airways related to a pathological mechanism of progressive airway destruction that is due to a 'vicious cycle' of recurrent bacterial infection, inflammatory mediator release, airway damage, and subsequent further infection. Antibiotics are the main treatment option for reducing bacterial burden in people with exacerbations of bronchiectasis and for longer-term eradication, but their use is tempered against potential adverse effects and concerns regarding antibiotic resistance. The comparative effectiveness, cost-effectiveness, and safety of different antibiotics have been highlighted as important issues, but currently little evidence is available to help resolve uncertainty on these questions.

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Macrolide antibiotics for bronchiectasis.

Cochrane Database Syst Rev

March 2018

Faculty of Health and Social Care, Edge Hill University, Ormskirk, UK.

Background: Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation and distortion of the smaller airways. Bacterial colonisation of the damaged airways leads to chronic cough and sputum production, often with breathlessness and further structural damage to the airways. Long-term macrolide antibiotic therapy may suppress bacterial infection and reduce inflammation, leading to fewer exacerbations, fewer symptoms, improved lung function, and improved quality of life.

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CT Characteristic of Early Local Recurrence After Resection of the Squamous Cell Carcinoma: Comparison With CT Characteristics of Stump Deformity or Granulation Tissue at Stump Site.

Medicine (Baltimore)

October 2015

From the Department of Radiology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Dongan-gu, Anyang-si, Gyeonggi-do (HJH); Departments of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-Gu, Seoul (MYK); Department of Healthcare Management, Cheongju University, Cheongwon-fu, Cheongju-si, Chungcheongbuk-do (S-SK); and Department of Pulmonary and Critical Care Medicine, and Division of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea (C-MC).

The aim of this study is to compare the thin section computed tomography (CT) characteristics of the early local tumor recurrence with those of the stump deformity or granulation tissue after the resection of squamous cell carcinoma (SCC).Twenty-nine consecutive patients with local recurrence after definitive SCC operation from April 2006 to September 2012 were included in our study. Pre- and postoperative CT findings from these patients were retrospectively reviewed and compared with those in the age- and sex-matched 29 patients with the stump deformity or granulation tissue at stump site after definitive SCC operation, by 2 radiologists.

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