Two women (aged 72 and 78 years) developed hepatitis due to clometacine. The main laboratory abnormalities were raised transaminases and blood eosinophil count. In one of these cases, in which the initial histological lesions had the appearance of aggressive chronic hepatitis, there was progression to cirrhosis despite the interruption of treatment. The mechanism of this hepatotoxicity is probably a hypersensitivity reaction.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[Adult multi-nuclear cell hepatitis. A study in 17 patients].
Gastroenterol Clin Biol
March 1998
Service d'Hépato-Gastroentérologie, Hôpital Jean-Verdier, Bondy.
Objectives: Giant-cell hepatitis is rare in adults and its significance has not been clarified. We report the clinical and histological characteristics and outcome in a group of adult patients with giant-cell hepatitis.
Methods: Seventeen patients with giant-cell hepatitis, hospitalized in our unit between 1976 and 1992, were studied retrospectively.
[Hepatitis caused by clometacin and asymptomatic primary biliary cirrhosis].
Ann Gastroenterol Hepatol (Paris)
November 1989
Service de Médecine interne et de Gastro-Entérologie, Hôpital André Mignot, Le Chesnay.
[Hepatitis caused by clometacin (Dupéran). Retrospective study of 30 cases. A model of autoimmune drug-induced hepatitis?].
Gastroenterol Clin Biol
October 1989
Services d'Hépato-Gastroentérologie, Hôpital de la Source, Orléans.
Thirty cases of clometacin-induced hepatitis were retrospectively collected over a nine-year period in hepatogastroenterological units of non university, public hospitals. There was a strong female predominance (90 percent). Clometacin (Dupéran) was taken because of arthritis in 8 out of 10 cases.
View Article and Find Full Text PDFVarious types of allergic accidents have been reported with clometacin (Duperan), a synthetic analgesic introduced in France in 1971. The most prominent is hepatitis in elderly women, with hyperglobulinemia, eosinophilia, autoantibodies and giant multinucleated hepatocytes. The case presented herein concerns a 73-year-old woman who, on two separate occasions after the ingestion of clometacin at recommended dosages, developed at the same time typical acute hepatitis and non-oliguric acute renal failure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!