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Organophosphorus Pesticides Management Strategies: Prohibition and Restriction Multi-Category Multi-Class Models, Environmental Transformation Risks, and Special Attention List.
Toxics
December 2024
Colleges of Forestry, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China.
Organophosphorus pesticides (OPs) have become one of the most widely used pesticides in Chinese agriculture; however, methods to identify potential restrictions on OPs molecules are lacking. Therefore, this study retrieved the OPs restriction list and constructed eight multi-class, multi-category machine learning models for OPs restrictions. Among these, the random forest (RF) model demonstrated excellent predictive performance, as it was successfully validated and applied.
View Article and Find Full Text PDFExtrapyramidal effects in a young child with acute organophosphorus insecticide poisoning.
Clin Toxicol (Phila)
January 2025
Department of Paediatrics, Poisons Information Center, Red Cross War Memorial Children's Hospital and University of Cape Town, South Africa.
Defect-Engineered Luminescent Nanozyme with Enhanced Phosphohydrolase Activity for Degradation and Dual-Mode Detection of Paraoxon.
Small
January 2025
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
The excessive use of organophosphorus pesticides poses a substantial threat to both human health and the environment. Consequently, there is an urgent need for new methods that can quickly degrade and sensitively detect these compounds. A versatile nanozyme based on the biomimetic principle is an effective strategy to solve this problem.
View Article and Find Full Text PDFN-acetylcysteine prevents cholinergic and non-cholinergic toxic effects induced by nerve agent poisoning in rats.
Toxicol Res (Camb)
February 2025
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India.
Objective: Organophosphorus Nerve Agent, VX [(O-Ethyl S-diisopropylaminomethyl) methylphosphonothioate] compound interferes with acetylcholine signaling by targeting the AChE enzyme. Studies suggest that in nerve agents poisoning, non-cholinergic effects are also responsible for damage in peripheral tissues including long term damage in brain. Present study reports cholinergic and non-cholinergic effects of VX poisoning and their prevention by use of N-acetylcysteine (NAC) in addition to conventional antidotes atropine sulphate and 2-PAM chloride as an antioxidant.
View Article and Find Full Text PDFA review of click chemistry in the synthesis of organophosphorus triazoles and their biological activities.
Eur J Med Chem
January 2025
Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha, 2713, Qatar. Electronic address:
Organophosphorus compounds, characterized by the incorporation of phosphorus into organic molecules, play a critical role in various fields such as medicine, agriculture, and industry. Their unique electronic properties and versatility make them essential in developing therapeutic agents, pesticides, and materials. One prominent class of organophosphorus compounds is organophosphorus heterocycles, which combine the benefits of both phosphorus and cyclic structures.
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