Craviten (M-71) or 2S, 2'S) N, N'-dimethyl-N, N'-bis [1-(3', 4', 5' -trimethoxy-benzoyloxy)-butyl-2]-ethylenediamine dihydrochloride an agent with a strong antiarrhythmic action has practically no effect on the central nervous system of rats and mice. It exerts no effect on the spontaneous motor activity, on amphetamine-stimulated hyperactivity, on rota-red performance, it has no analgesic and anticonvulsant action and does not change the hexobarbital sleeping time. No effects of Craviten were observed on the body temperature in rats and mice. It decreased the arterial blood pressure in rats and stimulated slightly respiration. The hypotensive effect was dose-dependent. The LD50 of the preparation is: rats: 142 mg/kg ip, 15 x 8 mg/kg iv; mice: 550 mg/kg ip; rabbits: 5 x 1 mg/kg iv.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Effect of butobendin on dopamine beta-hydroxylase in vitro.
Pol J Pharmacol
July 1997
Institute of Medical Biochemistry, Medical College of Jagiellonian University, Kraków, Poland.
It has been found that dopamine beta-hydroxylase (DBH) (E.C.1.
View Article and Find Full Text PDFEffects of buthobendin and epinephrine on glycolytic energy formation and magnesium concentration in vitro and in vivo.
Pol J Pharmacol Pharm
December 1991
Institute of Medical Biochemistry, Copernicus Medical Academy, Kraków, Poland.
Buthobendin activated glycolytic lactate formation stronger than epinephrine and increased the ATP level, both in vitro in rabbit myocardial slices and in vivo in rabbit blood. These effects were accompanied by an increase in extracellular magnesium concentration, which was probably related to the inhibitory effect of buthobendin on the membrane-bound ATPases.
View Article and Find Full Text PDFThe effect of buthobendin on glycolysis in rabbit myocardial slices in vitro.
Pol J Pharmacol Pharm
April 1989
Institute of Medical Biochemistry, N. Copernicus Medical Academy, Kraków, Poland.
The effect of buthobendin (2S,2'S isomer of N,N'-dimethyl N,N'-bis[1-(3',4',5'-trimethoxybenzoyloxy)-butyl-2]-ethylenediamin e dihydrochloride), (CravitenR) on aerobic and anaerobic glycolysis in rabbit myocardial slices was compared with that of the biologically inactive isomer 2R,2'R and the well-known antiarrhythmic drugs quinidine and procainamide. Only buthobendin stimulated lactate formation under anaerobic and aerobic conditions. However, that effect was not accompanied with a parallel increase in the glucose uptake, but was related to a decrease in the glycogen level.
View Article and Find Full Text PDFThe effect of buthobendin on human erythrocyte membrane ATPases.
Pol J Pharmacol Pharm
June 1988
Institute of Medical Biochemistry, N. Copernicus Academy of Medicine, Kraków, Poland.
The effect of buthobendin (CravitenR) on the ATPase activities/total (Na, K, Mg)-ATPase, and the ouabaine-sensitive (Na, K-ATPase) and insensitive (Mg-ATPase) fractions/from human erythrocyte membrane was examined in the presence or absence of liposomes. The activities of both ATPase fractions increased by 250% in the presence of 10 mmol/l phosphatidylcholine. Buthobendin inhibited both ATPases, but especially Na, K-ATPase.
View Article and Find Full Text PDFAmong 30 patients with ventricular arrhythmia resistant to conventional antiarrhythmic therapy, 33% showed normalization of heart rhythm after single i.v. injection of Craviten at a dose of 6 mg.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!