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HYPOTHALAMIC PITUITARY AXIS DYSFUNCTION IN A SEVERELY ASPHYXIATED NEONATE.
West Afr J Med
November 2024
Department of Paediatrics, Gombe State University and Federal Teaching Hospital, Gombe.
Introduction: Perinatal asphyxia is caused by a lack of oxygen to organ systems due to hypoxic or ischemic insult that occurs during labour and delivery. This may lead to multi-organ failure with brain involvement as the major organ of concern.
Case Report: We present a 19-day-old neonate referred to our centre with the complaint of inability to suck since birth and multiple seizures that started on the second day of life.
Methylation alterations of imprinted genes in different placental diseases.
Clin Epigenetics
September 2024
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, No.63 Duobao Road, Liwan District, Guangzhou, 510150, Guangdong, China.
Background: Imprinted genes play important functions in placentation and pregnancy; however, research on their roles in different placental diseases is limited. It is believed that epigenetic alterations, such as DNA methylation, of placental imprinting genes may contribute to the different pathological features of severe placental diseases, such as pre-eclampsia (PE) and placenta accreta spectrum disorders (PAS).
Results: In this study, we conducted a comparative analysis of the methylation and expression of placental imprinted genes between PE and PAS using bisulfite sequencing polymerase chain reaction (PCR) and quantitative PCR, respectively.
Perioperative complications of middle cerebral artery occlusion in rats alleviated by human umbilical cord mesenchymal stem cells.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Regenerative Medicine Research Center of The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Xishan District, 157 Jinbi Road, Kunming, 650000, Yunnan, China.
Article Synopsis
- Acute ischemic stroke treatments often face challenges like high complication rates, which negatively impact patient recovery and survival.
- Human umbilical cord mesenchymal stem cells (hucMSCs) show promise as a potential cell therapy due to their ability to differentiate and regulate immune responses.
- In a study conducted on rats, hucMSCs treatment improved neurological function, reduced brain tissue ischemia, enhanced postoperative survival, and lessened complications related to stress and anesthesia recovery following a stroke model.
Systematic Quantitative Analysis of Fetal Dexamethasone Exposure and Fetal Lung Maturation in Pregnant Animals: Model Informed Dexamethasone Precision Dose Study.
ACS Pharmacol Transl Sci
June 2024
Drug Clinical Trial Center, Peking University Third Hospital, Beijing 100191, China.
Dexamethasone (DEX) was applied in neonatal respiratory distress syndrome treatment of pregnant women. We established a pharmacokinetics (PK)/pharmacodynamics(PD)/end point model of pregnant animals based on published data and then extrapolated to simulate fetal exposure and lung maturation in pregnant women. We first established the PK/PD/end point model for DEX in pregnant sheep.
View Article and Find Full Text PDFEnhanced angiogenesis of human umbilical vein endothelial cells via THP-1-derived M2c-like macrophages and treatment with proteasome inhibitors 'bortezomib and ixazomib'.
APMIS
August 2024
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
The leading cause of cancer-related death is lung cancer, with metastasis being the most common cause of death. To elucidate the role of macrophages in lung cancer and angiogenesis processes, we established an in vitro co-culture model of A549 or HUVEC with THP-1 cells that polarized to M2c macrophages with hydrocortisone. The proteasome inhibitors bortezomib and ixazomib were investigated for their effects on proliferation, invasion, migration, metastasis, and angiogenesis pathways.
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