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Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia.
Br J Anaesth
July 2023
Department of Physiology and Biophysics, Rush University Medical Centre, Chicago, IL, USA.
Background: Most patients with malignant hyperthermia susceptibility diagnosed by the in vitro caffeine-halothane contracture test (CHCT) develop excessive force in response to halothane but not caffeine (halothane-hypersensitive). Hallmarks of halothane-hypersensitive patients include high incidence of musculoskeletal symptoms at rest and abnormal calcium events in muscle. By measuring sensitivity to halothane of myotubes and extending clinical observations and cell-level studies to a large group of patients, we reach new insights into the pathological mechanism of malignant hyperthermia susceptibility.
View Article and Find Full Text PDFScientific Accuracy Matters.
Anesthesiology
October 2021
From the Department of Anesthesia and Critical Care, Stanford University School of Medicine, Stanford, California; and the Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
The Solubility of Halothane in Blood and Tissue Homogenates. By Larson CP, Eger EI, Severinghaus JW. Anesthesiology 1962; 23:349-55.
View Article and Find Full Text PDFAbnormal calcium signalling and the caffeine-halothane contracture test.
Br J Anaesth
January 2019
Malignant Hyperthermia Investigation Unit of the University Health Network, Toronto, ON, Canada; Department of Anaesthesia & Pain Management, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
Background: The variable clinical presentation of malignant hyperthermia (MH), a disorder of calcium signalling, hinders its diagnosis and management. Diagnosis relies on the caffeine-halothane contracture test, measuring contraction forces upon exposure of muscle to caffeine or halothane (F and F, respectively). Patients with above-threshold F or F are diagnosed as MH susceptible.
View Article and Find Full Text PDFAnesthetics Have Different Effects on the Electrocorticographic Spectra of Wild-type and Mitochondrial Mutant Mice.
Anesthesiology
October 2018
From the Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington (C.W.C., S.C., F.K., M.M.S., P.G.M.) the Department of Anesthesiology and Pain Medicine (C.W.C., M.M.S., P.G.M.) the Division of Medical Genetics, Department of Medicine (S.C.) the Department of Neurological Surgery (F.K.), University of Washington, Seattle, Washington.
What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Knockout of the mitochondrial protein Ndufs4 (Ndufs4[KO]) in mice causes hypersensitivity to volatile anesthetics but resistance to ketamine. The authors hypothesized that electrocorticographic changes underlying the responses of Ndufs4(KO) to volatile anesthetics and to ketamine would be similar in mutant and control mice.
Methods: Electrocorticographic recordings at equipotent volatile anesthetic concentrations were compared between genotypes.
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