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The International Association for the Study of Lung Cancer Staging Project: The Database and Proposal for the Revision of the Staging of Pulmonary Neuroendocrine Carcinoma in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer.
J Thorac Oncol
January 2025
Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
Introduction: Pulmonary high-grade neuroendocrine carcinoma (NEC) includes small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC). The seventh and eighth editions of the TNM classification for lung cancer confirmed the applicability of this staging system for SCLC. With the proposal of N2 and M1c subcategories for the ninth edition classification, we assessed the applicability to NECs.
View Article and Find Full Text PDFLow-Waste Technology for High-Precision Connecting Rod Forging Manufacturing.
Materials (Basel)
January 2025
Department of Metal Forming, Welding and Metrology, Wroclaw University of Science and Technology, Lukasiewicza Street 5, 50-370 Wroclaw, Poland.
This study refers to the application of an advanced tool in the form of numerical modelling in order to develop a low-waste hot die forging technology to produce a connecting rod forging. The technology aims at ensuring a limited amount of the charge material is necessary to produce one forging, as well as minimizing forging forces, and thus the electric energy consumption. The study includes a verification of the current production technology, which constituted the basis for the construction and development of a numerical model.
View Article and Find Full Text PDFFinite Element Simulation of Hot Rolling for Large-Scale AISI 430 Ferritic Stainless-Steel Slabs Using Industrial Rolling Schedules-Part 1: Set-Up, Optimization, and Validation of Numerical Model.
Materials (Basel)
January 2025
Department of Materials Science and Metallurgical Engineering and Inorganic Chemistry, Faculty of Sciences, University of Cadiz, Campus Río San Pedro S/N, 11510 Cadiz, Spain.
A growing need to reduce the environmental impact and cost of manufacturing stainless steels has led to the development of ferritic stainless steel as an alternative to austenitic and duplex steels. The development of new stainless steels involves the optimization of their hot rolling processes, with the aim of minimizing the occurrence of defects and improving productivity. In this context, numerical simulation using the finite element method (FEM) is presented as a key tool to reduce the time and cost associated with traditional trial-and-error optimization methods.
View Article and Find Full Text PDFLarge language model based mutations in genetic improvement.
Autom Softw Eng
January 2025
Johannes Gutenberg University Mainz, Mainz, Germany.
Ever since the first large language models (LLMs) have become available, both academics and practitioners have used them to aid software engineering tasks. However, little research as yet has been done in combining search-based software engineering (SBSE) and LLMs. In this paper, we evaluate the use of LLMs as mutation operators for genetic improvement (GI), an SBSE approach, to improve the GI search process.
View Article and Find Full Text PDFConstitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei.
Sci Rep
January 2025
Sorbonne Université, CNRS, Inserm, Centre d'Immunologie et des Maladies Infectieuses, CIMI, F-75013 Paris, France.
Malaria is caused by protozoan parasites of the genus Plasmodium and remains a global health concern. The parasite has a highly adaptable life cycle comprising successive rounds of asexual replication in a vertebrate host and sexual maturation in the mosquito vector Anopheles. Genetic manipulation of the parasite has been instrumental for deciphering the function of Plasmodium genes.
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