California killifish (Fundulus parvipinnis) trapped in a Southern California estuary were infested with Gyrodactylus sp, Argulus sp, or Ergasilus sieboldii. They were treated with 0,0-dimethyl 2,2,2-trichloro-1-hydroxyethylphosphonate (DTHP). The effective dosage regimen for Gyrodactylus was 7.50 mg/l for 1 hour on day 1, 3.25 mg/l for 1 hour on day 5, and 0.75 mg/l for 1 hour on day 9; for Argulus, 2.50 mg/l for 1 hour once only; for Ergasilus, 2.50 mg/l for 1 hour once every third day for three treatments. Toxicity testing indicated that repetitive doses of 4.20 mg/l were toxic and that static exposures of more than 1 hour to doses of 7.50 mg/l were lethal to Fundulus.
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Front Pharmacol
January 2025
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease in the world. However, the current conventional approaches have not yet achieved satisfactory efficacy. As one of the most influential products in botanical medicine, L.
View Article and Find Full Text PDFPLoS One
January 2025
Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: A single dose of intraperitoneal (IP) meropenem is recommended for peritoneal-dialysis (PD)-related peritonitis stemming from extended-spectrum β-lactamase-producing organisms. However, data on IP meropenem is limited.
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Sci Rep
January 2025
Department of Fisheries, Faculty of Natural Resources, Isfahan University of Technology, Isfahan, 84156-8311, Iran.
The point of our study was to examine the interaction of ammonia-N poisoning and salinity on serum enzymes and oxidative stress factors of blood and liver in Nile tilapia (Oreochromis niloticus). The 50% lethal concentration (LC) in 96 h was 0.86 mg/L of ammonia-N.
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Department of Oncology, Suzhou Ninth People's Hospital, Suzhou 215200, Jiangsu Province, China.
Background: Surgical palliative surgery is a common method for treating patients with middle and late stage gastrointestinal tumors. However, these patients generally experience high levels of cancer pain, which can in turn stimulate the body's stress and undermine the effect of external surgery. Although opioid drugs have a significantly positive effect on controlling cancer pain, they can induce adverse drug reactions and potential damage to the body 's immune function.
View Article and Find Full Text PDFFront Microbiol
December 2024
Veterinary Pharmacotherapy and Pharmacy, Department of Population Health Sciences, Utrecht University, Utrecht, Netherlands.
Introduction: A harmonized clinical breakpoint for interpreting antimicrobial susceptibility testing of oxytetracycline in cattle is currently lacking in Europe. This study aimed to establish a pharmacokinetic/pharmacodynamic (PK/PD) cutoff to propose clinical breakpoints, facilitating reliable interpretation of antimicrobial susceptibility results in cattle.
Methods: A meta-analysis of oxytetracycline pharmacokinetic data from 69 cattle was conducted, including 1,730 plasma concentration samples from animals administered 20 mg/kg intramuscularly and/or 20 or 40 mg/kg intravenously.
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