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Alterations in Ileal Microbiota and Fecal Metabolite Profiles of Chickens with Immunity to .
Animals (Basel)
December 2024
Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Minhang, Shanghai 200241, China.
Coccidiosis, caused by different species of parasites, is an economically important disease in poultry and livestock worldwide. This study aimed to investigate the changes in the ileal microbiota and fecal metabolites in chickens after repeated infections with low-dose . The chickens developed solid immunity against a high dose of infection after repeated infections with low-dose .
View Article and Find Full Text PDFAssociation between magnesium and vitamin D status in adults with high prevalence of vitamin D deficiency and insufficiency.
Eur J Nutr
December 2024
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, 8036, Austria.
Purpose: It has been assumed that magnesium (Mg) status may interact with vitamin D status. We therefore aimed at investigating the association between Mg and vitamin D status in a large cohort of adult individuals with a high prevalence of deficient/insufficient vitamin D and Mg status.
Methods: We used data from the Ludwigshafen Risk and Cardiovascular Health Study (n = 2,286) to analyze differences according to serum Mg status in circulating 25-hydroxyvitamin D [25(OH)D] (primary endpoint), 24,25-dihydroxyvitamin D [24,25(OH)D], vitamin D metabolite ratio and calcitriol, and odds ratios for deficient or insufficient 25(OH)D (secondary endpoints).
Measurement of 1,25-dihydroxyvitamin D in serum by LC-MS/MS compared to immunoassay reveals inconsistent agreement in paediatric samples.
Clin Chem Lab Med
December 2024
Bioanalytical Facility, Norwich Medical School, University of East Anglia, Norwich, UK.
Objectives: Automated immunoassays for 1,25-dihydroxyvitamin D (1,25(OH)D) have increased the use of serum measurements in clinical and research settings, but disagreement with LC-MS/MS methods remains an issue.
Methods: In this study, we examined this problem using samples obtained from healthy young adults, n=80, mean age 21.7 (18-32) years, and a large cohort of paediatric samples, n=422, mean age 7.
Population Pharmacokinetic Model of Vitamin D and Metabolites in Chronic Kidney Disease Patients with Vitamin D Insufficiency and Deficiency.
Int J Mol Sci
November 2024
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Article Synopsis
- - Vitamin D insufficiency and deficiency are common in chronic kidney disease (CKD) patients, prompting a study to create a pharmacokinetic model for oral cholecalciferol (VitD) and its metabolites in this population.
- - The study involved 29 CKD patients who were given a single dose of oral VitD, using nonlinear mixed effects modeling to analyze how the drug and its metabolites are processed in the body.
- - The results indicate that personalized dosing strategies of 600 to 1000 I.U. of VitD per day may be ideal for reaching target 25-hydroxyvitamin D levels, potentially improving treatment for CKD patients.
Regulatory mechanisms and pathological implications of CYP24A1 in Vitamin D metabolism.
Pathol Res Pract
December 2024
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India. Electronic address:
CYP24A1 is a crucial gene within the cytochrome P450 superfamily, responsible for encoding the enzyme 25-hydroxyvitamin D3-24-hydroxylase. This enzyme is involved in the catabolism of 1,25-dihydroxyvitamin D3, the biologically active form of vitamin D3, by hydroxylating its side chain. Through this process, CYP24A1 tightly regulates the bioavailability and physiological impact of vitamin D3 in the body.
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