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Iron-Reduced Graphene Oxide Core-Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light.
Pharmaceutics
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Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.
Core-shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to the limited penetration of near-infrared (NIR) light. In this study, we present a novel core-shell micromotor that combines magnetic and photothermal properties.
View Article and Find Full Text PDFMaximum tolerated dose and toxicity evaluation of orally administered docetaxel granule in mice.
Toxicol Rep
June 2024
Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA.
Oral delivery of chemotherapy drugs is the most favorable and preferred route of drug administration. However, because of poor solubility and/or permeability, most chemotherapy drugs are given by intravenous administration. Docetaxel (DTX) is a potent chemotherapy drug that inhibits microtubular depolymerization and is widely used to treat numerous cancers.
View Article and Find Full Text PDFTemplate-Free Self-Assembly of Hollow Microtubular Covalent Organic Frameworks for Oral Delivery of Insulin.
ACS Appl Mater Interfaces
April 2024
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
Covalent organic frameworks (COFs) have demonstrated versatile application potential since their discovery. Although the structure of COFs is orderly arranged, the synthesis of controllable macrostructures still faces challenges. Herein, we report, to our knowledge, the first template-free self-assembled COF-18 Å hollow microtubule (MT-COF-18 Å) structure and its use for insulin delivery that exhibits high loading capacity, gastroresistance, and glucose-responsive properties.
View Article and Find Full Text PDFAshwagandha- Withania somnifera (L.) Dunal as a multipotent neuroprotective remedy for genetically induced motor dysfunction and cellular toxicity in human neurodegenerative disease models of Drosophila.
J Ethnopharmacol
January 2024
Developmental Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Mysuru, 570006, India. Electronic address:
Ethnopharmacological Relevance: Ashwagandha-Withania somnifera (L.) Dunal, well known for its multipotent therapeutic properties has been used in Ayurveda for 3000 years. The plant with more than 50 active phytoconstituents is recognised for its anti-cancerous, anti-diabetic, anti-inflammatory, anti-microbial, and neurotherapeutic properties demonstrated in in vitro studies and chemically induced rodent models.
View Article and Find Full Text PDFClonogenic Assays to Detect Cell Fate in Mitotic Catastrophe.
Methods Mol Biol
June 2021
Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, Paris, France.
Article Synopsis
- Mitotic catastrophe (MC) is a type of cell death caused by DNA damage that activates checkpoints in the cell cycle, leading to abnormal cell division, and can result in either cell death or senescence.
- Suppressing MC can lead to aneuploidy, which is linked to cancer, and various cancer treatments like microtubule inhibitors and radiation can induce MC.
- A new technique using human colon cancer HCT116 cells that express specific proteins allows researchers to analyze cell proliferation and observe changes in the nucleus and centrosomes, addressing limitations of traditional clonogenic assays.
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