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Separate and combined blockades of α- and β-adrenergic receptors in forearm sweating induced by adrenergic agents and exercise in the heat in young adults.
Am J Physiol Regul Integr Comp Physiol
February 2025
Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.
The assessment of adrenergic modulation of sweating as assessed via pharmacologic administration of α- and β-adrenergic receptor blockers during exercise has yielded mixed findings. However, the underlying mechanisms for this disparity remain unresolved. We investigated the effects of separate and combined blockade of α- and β-adrenergic receptors on forearm sweating induced by a 30-min moderate-intensity exercise bout ( = 17, ) and the administration of adrenergic agonists epinephrine and norepinephrine ( = 16, ) in the heat.
View Article and Find Full Text PDFEffect of gelatin nanoparticles' size and charge on iontophoretic targeted deposition to the hair follicles.
Int J Pharm
December 2024
Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbrücken, Germany. Electronic address:
Hair follicles (HFs) represent a route of interest to drug delivery for treating several skin conditions. Iontophoresis, on the other hand, is a physical method to enhance drug permeation by applying a low electrical current to the formulation. HFs can be targeted following topical iontophoretic application, as they represent a pathway of lower electrical resistance, as well as a drug reservoir, in particular useful for nanoparticles (NPs), which can preferably accumulate in these structures.
View Article and Find Full Text PDFEffect of iontophoresis on dacarbazine cutaneous delivery for melanoma topical treatment.
Int J Pharm
November 2024
Laboratory of Food, Drugs, and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70910-900, Brasília, DF, Brazil. Electronic address:
Dacarbazine (DTIC) is the drug of choice for melanoma treatment, but its systemic administration is related to several adverse effects. Here, DTIC topical delivery stimulated by iontophoresis is proposed to overcome such drawbacks. Hence, this work analyzed the impact of anodal iontophoresis on DTIC cutaneous delivery to provide an innovative topical alternative for melanoma treatment.
View Article and Find Full Text PDFFunctional-hydrogel-based electronic-skin patch for accelerated healing and monitoring of skin wounds.
Biomaterials
March 2025
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea; School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address:
Conductive hydrogels feature reasonable electrical performance as well as tissue-like mechanical softness, thus positioning them as promising material candidates for soft bio-integrated electronics. Despite recent advances in materials and their processing technologies, however, facile patterning and monolithic integration of functional hydrogels (e.g.
View Article and Find Full Text PDFDepolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers.
PLoS One
August 2024
Experimental Pain Research, MCTN, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
The majority of somatosensory DRG neurons express GABAA receptors (GABAAR) and depolarise in response to its activation based on the high intracellular chloride concentration maintained by the Na-K-Cl cotransporter type 1 (NKCC1). The translation of this response to peripheral nerve terminals in people is so far unclear. We show here that GABA (EC50 = 16.
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