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[Implementation of edoxaban anti-Xa activity assay in a hospital laboratory and evaluation of its analytical performance].
Ann Biol Clin (Paris)
September 2024
Service d'Hématologie Biologique, Assistance Publique Hôpitaux de Paris-Centre (AP-HP.CUP), F-75015 Paris, France, Université Paris Cité, Innovative Therapies in Haemostasis, INSERM, 75006 Paris, France, INNOVTE, F-CRIN, Saint-Étienne, France.
Article Synopsis
- Edoxaban is a direct oral anticoagulant not available in France, making it important to understand its pharmacology and lab testing, especially with high tourist traffic.
- The study focused on measuring the anti-Xa activity of edoxaban using a specific chromogenic method, detailing pre-analytical and analytical processes for accurate therapeutic guidance.
- Results showed the measurement method to be reliable and straightforward, suggesting that even though it's seldom used clinically, having the ability to measure edoxaban levels in French hospitals is important due to its availability in nearby countries.
Clinico-biological factors predicting the benefit of the LV5FU2 maintenance strategy as a first-line therapy in patients with metastatic pancreatic cancer.
Oncologist
September 2024
Department of Gastroenterology, University Hospital Pontchaillou, Rennes 1 University, INSERM U1242 "Chemistry Oncogenesis Stress Signalling," Rennes, France.
Article Synopsis
- The study investigates predictive markers for the benefits of LV5FU2 maintenance therapy after first-line FOLFIRINOX treatment in patients with metastatic pancreatic cancer.
- It compares two patient groups from the PRODIGE-35 trial: one receiving 12 cycles of FOLFIRINOX, and another receiving 8 cycles followed by LV5FU2 maintenance.
- Results indicate that certain factors, like age and metastatic sites, affect patient outcomes, suggesting that LV5FU2 maintenance is generally beneficial except for some specific cases.
Investigating the prognostic impact of NY-ESO-1 expression and HLA subtypes in metastatic synovial sarcoma.
ESMO Open
August 2024
Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
Background: To better understand the importance of the New York esophageal squamous cell carcinoma 1 (NY-ESO-1) and human leukocyte antigen (HLA) subtypes in treatment decision-making, further investigation of their prevalence and prognostic impact among patients with metastatic synovial sarcoma (mSS) is needed.
Patients And Methods: This was a retrospective clinico-biological cohort study of adults with mSS. Patient data were collected from the French Sarcoma Group NetSARC database and supplemented by electronic medical records.
First-line infertility treatment in normal or subnormal sperm: Interest of a simplified pre-IMSI test.
PLoS One
July 2024
Department of Reproductive Biology, Nîmes University Hospital, Nîmes, France.
Article Synopsis
- The study aimed to create a simplified technique called the pre-IMSI test (PIT) to evaluate sperm morphology in infertile men, particularly those with normal or subnormal sperm, after multiple unsuccessful fertility treatments.
- Researchers selected 248 patients and categorized them into three subgroups based on their PIT scores, which measured the quality of motile sperm.
- Results showed that higher PIT scores were associated with better clinical pregnancy outcomes in ICSI procedures, highlighting the potential of the PIT as a predictive tool for ART success.
Step-up approach for the treatment of infected necrotising pancreatitis: real life data from a single-centre experience with long-term follow-up.
BMC Gastroenterol
June 2024
Department of Gastroenterology and Pancreatology, Toulouse Rangueil University Hospital, 1 avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, France.
Background: About 20% of patients with acute pancreatitis develop a necrotising form with a worse prognosis due to frequent appearance of organ failure(s) and/or infection of necrosis. Aims of the present study was to evaluate the "step up" approach treatment of infected necrosis in terms of: feasibility, success in resolving infection, morbidity of procedures, risk factors associated with death and long-term sequels.
Methods: In this observational retrospective monocentric study in the real life, necrotizing acute pancreatitis at the stage of infected walled-off necrosis were treated as follow: first step with drainage (radiologic and/or endoscopic-ultrasound-guided with lumen apposing metal stent); in case of failure, minimally invasive necrosectomy sessions(s) by endoscopy through the stent and/or via retroperitoneal surgery (step 2); If necessary open surgery as a third step.
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