The authors present and illustrate most of the ultrastructural abnormalities encountered in skeletal muscle in cases of neuromuscular disease. The diagnostic significance of the changes are discussed but emphasis is laid on the nonspecific character of most of them. For diagnostic purposes, examination by light microscopy remains the preferred approach, but electron microscopy enables the nature and origins of the lesions to be better defined and is a very valuable technique in exploring the pathogenesis of muscular diseases.
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