[Clinical pathophysiology and intensive therapy of diffuse peritonitis].

The work describes the results of an investigation of pathophysiological shifts and methods for their correction used in 204 patients with diffuse peritonitis. It is concerned with problems of diagnosis and therapy of protein, water-electrolyte disorders, acute respiratory insufficiency, "shock lung". Pharmacodynamic and pharmacokinetic properties of cephalosporins injected intravenously and intra-orally were studied. With antibiotics used as an indicator, the disturbances of processes of mixing and shunting the blood were revealed. The authors believe that patients with diffuse peritonitis should be subjected to intensive therapy under conditions of a reanimation department during 5-12 days.