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A Highly Sensitive Triple Quad LC-MS/MS Method Development and Validation for the Determination of Bexicaserin (LP352) in Human Plasma and Urine Matrices.
Biomed Chromatogr
February 2025
Department of Clinical Pharmacology and Pharmacometrics, Longboard Pharmaceuticals, Inc. is a part of Lundbeck as a wholly owned subsidiary of Lundbeck LLC, La Jolla, California, USA.
Bexicaserin is a highly selective agonist at the 5-HT receptor in clinical development for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). We report an LC-MS/MS method for the quantitative estimation of bexicaserin in human plasma and urine. The sample preparation involves the extraction of bexicaserin and internal standard (CD-bexicaserin; IS) from 150 μL plasma and 50 μL urine using a solid phase extraction method.
View Article and Find Full Text PDFDevelopment and validation of an LC-MS/MS method for quantification of Osimertinib and its two metabolites AZ7550 and AZ5104 in human plasma including long-time storage.
J Pharm Biomed Anal
March 2025
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.
Osimertinib (AZD9291) is a widely used tyrosine kinase inhibitor for the treatment of non-small cell lung cancer patients with activating EGFR mutations. However, the correlation between dose and efficacy has been debated for several years. For this reason, there is a need for standardized methods for routine analysis, clinical studies on pharmacokinetics and dose-response relationships, and greater understanding of preanalytical conditions, such as sample storage stability.
View Article and Find Full Text PDFLife-course perspective on the causal mechanism of social functioning in schizophrenia spectrum disorder.
Int J Soc Psychiatry
December 2024
Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Background: Due to prior emphasis on clinical recovery in Schizophrenia Spectrum Disorder (SSD), improving social functioning (SF) was oftentimes neglected, with ⩽15% of patients achieving social recovery. Priorly, we and others have shown that life-course factors, including childhood adversities, play a role in the occurrence and severity of postmorbid SF impairments, highlighting the need to understand these factors for effective interventions.
Aim: This study investigates the mechanisms influencing SF in SSD and examines the causal roles of childhood trauma, premorbid adjustment, perceived stigma, self-esteem, and quality of life.
Enduring effects of psychotherapy, antidepressants and their combination for depression: a systematic review and meta-analysis.
Front Psychiatry
November 2024
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freilburg, Germany.
Introduction: Although depressive disorders are frequently associated with relapses, the sustained efficacy of therapies after their termination has been insufficiently investigated.
Objective: The aim of this study was to evaluate the current evidence of enduring effects of psychotherapy, antidepressants and their combination after the end of treatment.
Methods: PubMed and PsychINFO were systematically screened according to PRISMA guidelines (except for preregistration).
Habitat Changes at the Local Scale Have Major Impacts on Waterfowl Populations Across a Migratory Flyway.
Glob Chang Biol
December 2024
Estación Biológica de Doñana, Sevilla, Spain.
Article Synopsis
- * A study of the Guadalquivir marshes in Spain revealed that changes in wintering waterbird populations over 40 years are linked to environmental shifts in the area, affecting biogeographical populations in the East Atlantic Flyway.
- * The results highlight the need to consider both local wetland changes and global environmental factors, like rising winter temperatures, when assessing trends in migratory species, underlining the importance of protecting migratory flyways internationally.
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