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A Case Report of Meningitis Caused by Biovar 3.

Infect Drug Resist

December 2024

State International Joint Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, People's Republic of China.

Background: Brucellosis, a major endemic disease in northern China, is contracted by zoonosis of . We report a case of meningitis caused by biovar 3.

Case Presentation: A 46-year-old man was hospitalized at a local medical facility due to symptoms of fever, soreness, and weakness on April 16, 2021.

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Brucellosis, a chronic zoonotic disease with a significant global burden, particularly in endemic areas, can also present as neurobrucellosis, a rare complication. We report a case of polyradiculoneuropathy in a pediatric patient resulting from this uncommon presentation. A 5-year-old girl presented with progressive asymmetric lower limb weakness for two weeks that progressed to a loss of ambulation in four weeks.

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A young male adult presented with a two-week-long history of myoarthralgia, vomiting, febrile sensation, holocranial headache with photophobia, neck stiffness, anorexia, and weight loss. He worked as a butcher in a local slaughterhouse, and two of his coworkers had recently been diagnosed with brucellosis. On his fourth visit to the Emergency Department (ED), fever was observed for the first time.

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Article Synopsis
  • * In a study of seven NB cases, signs of increased intracranial pressure were prominent, including symptoms like blurred vision and nerve palsy, while MRI scans revealed various brain abnormalities.
  • * All patients tested negative for Brucella in blood and CSF serology, but the diagnosis was confirmed using molecular techniques like PCR, highlighting the need for these advanced methods in suspected cases of NB.
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Article Synopsis
  • The study aimed to assess the importance of immune cells and biochemical markers found in cerebrospinal fluid and blood for diagnosing Brucella meningitis in patients.
  • Conducted on 90 patients divided into three groups, it analyzed clinical data and the levels of specific immune markers to determine their association with Brucella meningitis.
  • Results showed that certain immune cells and biochemical markers like C-Glu and C-LDH could significantly help in diagnosing Brucella meningitis, with their combined use offering high predictive accuracy.
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