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[The functional role and properties of transcortin in the human body].
Probl Endokrinol (Mosk)
August 2024
Steroid hormones take an active part in a whole complex of physiological processes that are fundamental for the normal development and functioning of the human body. In the bloodstream steroid hormones are bind with specific transport proteins, in particular with transcortin. The matter of changes in hormone-protein complex in various conditions were actively studied in the second half of the twentieth century, but currently this issue has been taken a back seat by the development of high-precision diagnostic methods of steroid hormones determining.
View Article and Find Full Text PDFThe NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure.
Nat Commun
January 2025
University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing 'free' glucocorticoid levels at sites of inflammation. NE is inhibited by alpha-1-antitrypsin (AAT; SERPINA1).
View Article and Find Full Text PDFMass spectrometric detection of neutrophil elastase cleaved corticosteroid binding globulin and its association with Asn347 site glycosylation, in septic shock patients.
Clin Chim Acta
February 2025
Department of Medicine, University of Adelaide, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Australia; Endocrine and Diabetes Services, The Queen Elizabeth Hospital, Australia.
Background: Corticosteroid-binding globulin (CBG) modulates tissue cortisol availability via modification of cortisol:CBG binding affinity in response to multiple factors, including neutrophil elastase (NE) cleavage of the reactive centre loop (RCL), converting high affinity CBG (haCBG) to low affinity CBG (laCBG). In vitro, glycosylation of the RCL at Asn347 affects NE cleavage susceptibility. To date, no direct measurement of laCBG, which would verify NE cleavage, has been reported.
View Article and Find Full Text PDFGenetic Variation of Hypothalamic-Pituitary-Adrenal Axis Activity in Farm Animals and Beyond.
Neuroendocrinology
December 2024
GenPhySE, Université de Toulouse, INRAE, INPT, ENVT, Toulouse, France.
Article Synopsis
- * Key sources of genetic variability identified include the adrenal cortex's response to ACTH, how corticosteroid hormones are utilized in the body, and the function of glucocorticoid receptors, with single mutations having different effects based on genetic context.
- * Understanding these genetic factors can lead to advanced breeding strategies that enhance stress resilience and productivity in farm animals, with future research focusing on the comprehensive genetic interactions affecting HPA axis function.
Regulation of corticosteroid-binding globulin release in murine leydig tumor cell line mLTC-1 by luteinizing hormone and interleukin-6.
Arch Biochem Biophys
November 2024
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China. Electronic address:
Exogenous assaults interfere with homeostatic processes in the body by inducing stress responses. Corticosteroid-binding globulin (CBG) binds to stress hormone glucocorticoids to transport and dynamically control their availability to target tissues. In our previous study, we confirmed that CBG is locally produced by Leydig cells in the testes.
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