Weak electrical stimuli were applied to sensory fibers of the median nerve at the wrist, and the ascending action potentials were recorded at the elbow. This was done with or without a preceding conditioning stimulus to test for supernormal excitability to the second stimulus. In the resting nerve, supernormal excitability was present from 3 to 20 msec after a conditioning shock. After a period of ischemia, excitability was both exaggerated and prolonged. This observations confirms the presence in sensory fibers of a phenomenon previously described in motor fibers.
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http://dx.doi.org/10.1002/mus.880040113 | DOI Listing |
Clin Pharmacol Ther
December 2024
Centre for Human Drug Research, Leiden, The Netherlands.
NMD670 is a first-in-class inhibitor of skeletal muscle-specific chloride channel ClC-1, developed to improve muscle weakness and fatigue in neuromuscular diseases. Preclinical studies show that ClC-1 inhibition enhances muscle excitability, improving muscle contractility and strength. We describe the first-in-human, randomized, double-blind, placebo-controlled study, which evaluated the safety, pharmacokinetics, and pharmacodynamics of single and multiple doses of NMD670 in healthy male and female subjects.
View Article and Find Full Text PDFInorg Chem
October 2024
State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Eastern South Lake Road, Changchun 130033, China.
Fluorescence intensity ratio (FIR)-type optical thermometers based on thermally coupled energy levels (TCLs) of rare earth ions are suitable candidates for noncontact temperature detection in living organisms, microelectronics apparatus, and so forth. Therefore, the improvement of the thermometric sensitivity of TCL-based thermometers has become a research hotspot in recent years. Herein, ultrahigh sensitivity and outstanding resolution for temperature sensing have been realized in YNbO: Yb/Er.
View Article and Find Full Text PDFClin Neurophysiol
November 2024
Centre Hospitalier Universitaire de Liège, Department of Neurophysiology, Sart Tilman B35, 4000 Liège, Belgium. Electronic address:
Objective: To validate the 'paired pulses' technique with a conventional electrodiagnostic machine (CEM) for studying the axonal excitability recovery cycle (ERC).
Methods: Paired pulses, with a variable inter-stimulus interval, were delivered at the wrist along the median nerve. The CEM repeatability was verified in a group of 15 healthy volunteers (test/retest analysis).
J Electrocardiol
September 2024
University of Health Sciences, Ankara Bilkent City Hospital, Department of Cardiology, Ankara, Turkey.
Bigeminy is a cardiac arrhythmia in which there is a single ectopic beat, or irregular heartbeat, following each regular heartbeat. This case demonstrates the diagnostic challenges that can be encountered while interpreting ECGs of patients with "apparent ventricular bigeminy'.
View Article and Find Full Text PDFGastro Hep Adv
October 2023
Division of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, California.
Esophageal peristalsis involves a sequential process of initial inhibition (relaxation) and excitation (contraction), both occurring from the cranial to caudal direction. The bolus induces luminal distension during initial inhibition (receptive relaxation) that facilitates smooth propulsion by contraction travelling behind the bolus. Luminal distension during peristalsis in normal subjects exhibits unique characteristics that are influenced by bolus volume, bolus viscosity, and posture, suggesting a potential interaction between distension and contraction.
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