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Combination drug therapy prevents CIAKI by suppressing ER stress-induced apoptosis.
Sci Rep
December 2024
Department of Cardiology, Tianjin Chest Hospital, No. 261 of Taierzhuang South Road, Tianjin, 300121, China.
Contrast-induced acute kidney injury (CIAKI) is an important clinical complication that occurs after the application of contrast agent in percutaneous coronary intervention. The pathogenesis of CIAKI is complex. Studies have shown that cell apoptosis induced by endoplasmic reticulum stress (ERS) plays an important role in renal tubular injury in CIAKI.
View Article and Find Full Text PDFContractile responses of engineered human myometrium to prostaglandins and inflammatory cytokines.
APL Bioeng
December 2024
Laboratory for Living Systems Engineering, Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, California, 90089, USA.
Preterm labor is a prevalent public health problem and occurs when the myometrium, the smooth muscle layer of the uterus, begins contracting before the fetus reaches full term. Abnormal contractions of the myometrium also underlie painful menstrual cramps, known as dysmenorrhea. Both disorders have been associated with increased production of prostaglandins and cytokines, yet the functional impacts of inflammatory mediators on the contractility of human myometrium have not been fully established, in part due to a lack of effective model systems.
View Article and Find Full Text PDFThe therapeutic effect of different cumin essential oil fractions against gastric ulcer in rats.
J Food Sci
December 2024
Department of emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Cumin, a popular spice, is widely used to treat stomach ailments in Central Asia and Xinjiang, China. Cumin essential oil has been found to effectively treat gastric ulcers, but its pharmacodynamic basis remains unclear. In this study, cumin essential oil was directly separated using column chromatography, and its components were identified through multi-dimensional gas chromatography-mass spectrometry.
View Article and Find Full Text PDFGallein increases prostaglandin F2α‑induced osteoprotegerin and IL‑6 secretion in osteoblasts.
Biomed Rep
November 2024
Department of Pharmacology, Gifu University, Gifu 501-1194, Japan.
Gallein is a known Gβγ subunit inhibitor, but its function in bone metabolism, especially in osteoblasts, and its molecular mechanism remains to be elucidated. Osteoprotegerin (OPG), which is secreted from osteoblasts, binds to nuclear factor kB receptor activator (RANK) ligand (RANKL) as a decoy receptor, prevents RANKL-RANK binding, and inhibits bone resorption. IL-6 is not only a bone resorption factor but also as a bone metabolism regulator.
View Article and Find Full Text PDFEffects of exercise on cAMP-mediated platelet inhibition in young women: a pilot study.
Eur J Appl Physiol
December 2024
UCD School of Medicine, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
Purpose: Exercise has been shown to reduce platelet reactivity and increase platelet sensitivity to prostacyclin, an endothelium-derived inhibitor of platelet activation, in middle-aged men and women. It is currently unknown if these beneficial effects can also be observed in young women and the intracellular mechanisms involved have not been identified. In this study, the feasibility of detecting changes in platelet reactivity, prostacyclin sensitivity and cAMP signalling were tested.
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