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Quercetin loaded biogenic squalene nano-lipid carriers for the treatment of dry eye syndrome.
Int J Pharm
March 2025
School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India. Electronic address:
In this study, quercetin-incorporated squalene nanostructured lipid carriers (QS-NLCs) were developed to mitigate the pathological conditions of dry eye disease (DED). The melt emulsification method was used to prepare QS-NLCs. The resulting NLCs have 93.
View Article and Find Full Text PDFChitosan-alginate microcapsules: A strategy for improving stability and antibacterial potential of bovine Lactoferrin.
Int J Biol Macromol
March 2025
Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados, Consejo Nacional de Investigaciones Científicas y Técnicas (IITEMA, CONICET), Universidad Nacional de Río Cuarto (UNRC), Río Cuarto 5800, Córdoba, Argentina. Electronic address:
Lactoferrin, a multifunctional glycoprotein with significant biological properties, presents significant potential for the prevention and treatment of infectious diseases. However, the effectiveness of oral Lactoferrin is limited by its susceptibility to degradation in harsh stomach conditions, reducing its bioavailability and therapeutic efficacy. To address this challenge, this study employs Chitosan/Alginate microparticles to enhance Lactoferrin stability and antibacterial activity.
View Article and Find Full Text PDFSpatiotemporal trends of aerosol provenance and trace metal concentrations in the northeast subarctic Pacific Ocean.
Sci Total Environ
March 2025
Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, V6T 1Z4, Canada.
The long-range transport of naturally occurring and anthropogenic aerosols originating from Asian deserts and megacities, respectively, can have a significant impact on the biogeochemical cycling of metals in the Fe-limited, high nutrient-low chlorophyll (HNLC) region of the northeast (NE) subarctic Pacific Ocean. These aerosols can deposit essential (e.g.
View Article and Find Full Text PDFImpaired denitrification of aerobic granules in response to micro/nanoplastic stress: Insights from interspecies interactions and electron transfer processes.
Water Res
March 2025
National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, China.
The accumulation of micro/nanoplastics in wastewater significantly hinders denitrification in biological wastewater treatment systems, yet the intrinsic mechanisms are not fully understood. Herein, we combined signal molecule monitoring, electrochemical characterization and multi-omics analysis to investigate how quorum sensing (QS)-mediated microbial interactions influence denitrification in aerobic granular sludge systems. Results showed that after 90-day exposure to micro/nanoplastics, cross-talk between multiple signal molecules significantly declined, thereby disrupting the QS system to opportunely sense changes in the external environment.
View Article and Find Full Text PDFUnifiedGreatMod: A New Holistic Modelling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale.
Bioinformatics
March 2025
Department of Computer Science, University of Turin, Torino, 10123, Italy.
Motivation: Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognisable from the biological and clinical community is the possibility of quickly inspecting the whole system, bearing in mind the different granularity levels of its components. This holistic view of system behaviour expands the evolution study by identifying the heterogeneous behaviours applicable, for example, to the cancer evolution study.
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