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Background: Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed.

Methods: G6PDd participants with P.

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Article Synopsis
  • A 29-year-old pregnant woman from Equatorial Guinea experienced severe malaria due to Plasmodium falciparum, leading to complications such as cerebral malaria and acute kidney injury (AKI), necessitating renal replacement therapy and a kidney biopsy.
  • During her hospitalization, various tests confirmed her malaria diagnosis, and she was treated with antimalarial medications while experiencing significant symptoms including hypotension and haematological issues.
  • The kidney biopsy revealed active tubulointerstitial nephritis, and after intensive dialysis, her kidney function improved, allowing for a successful cesarean delivery and subsequent recovery without deterioration in kidney health.*
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Unmasking hidden risks: A case of primaquine-induced intravascular hemolysis in G-6-PD deficient malaria patient.

Travel Med Infect Dis

October 2024

Thai Travel Clinic, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand. Electronic address:

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Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173.

Acta Crystallogr F Struct Biol Commun

October 2024

Chemistry and Biochemistry Department, Hampton University, 200 William R. Harvey Way, Hampton, VA 23668, USA.

Article Synopsis
  • Plasmodium vivax causes malaria, affecting about a third of the world's population, and primaquine treatment is unsafe for those with G6PD deficiency, which impacts a significant portion of people in endemic areas.
  • The Seattle Structural Genomics Center for Infectious Disease studied PvNMT (N-myristoyltransferase) to find alternative drug targets since it's essential for P. vivax survival by facilitating protein modification.
  • The newly solved crystal structure of PvNMT, showing its interaction with myristoyl-CoA and a novel inhibitor, reveals differences from human enzymes, providing insights for creating effective antimalarial drugs.
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