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Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.
Am J Physiol Renal Physiol
November 2024
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Inadequate dietary potassium (K) consumption is a significant contributor to poor cardiovascular outcomes. A diet with reduced K content has been shown to cause salt-sensitive increases in blood pressure. More recently, we have also shown that reductions in blood K can cause direct kidney injury, independent of dietary sodium (Na) content.
View Article and Find Full Text PDFT18/S19 diphosphorylation of myosin regulatory light chain impairs pulmonary artery relaxation in monocrotaline-induced pulmonary hypertensive rats.
Pflugers Arch
September 2023
Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Phosphorylation of Ser19 (S19-p) on the myosin regulatory light chain (MLC2) is critical for arterial contraction. It has been shown that elevated RhoA-dependent kinase (ROCK) activity or decreased MLC phosphatase (MLCP) activity leads to further phosphorylation of Thr18 (T18/S19-pp), which has been linked to vasospastic diseases. However, this phenomenon has not yet been studied in the context of pulmonary arterial hypertension (PAH).
View Article and Find Full Text PDFShort-term effects of the chemical components of fine particulate matter on pulmonary function: A repeated panel study among adolescents.
Sci Total Environ
October 2023
Department of Public Health, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo 663-8501, Japan.
The effects of the chemical components of fine particulate matter (PM) have been drawing attention. However, information regarding the impact of low PM concentrations is limited. Hence, we aimed to investigate the short-term effects of the chemical components of PM on pulmonary function and their seasonal differences in healthy adolescents living on an isolated island without major artificial sources of air pollution.
View Article and Find Full Text PDFHigh sodium intake does not worsen low potassium-induced kidney damage.
Physiol Rep
April 2023
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
High sodium and low potassium intake have both been linked to poor cardiovascular health outcomes and increased mortality rates. A combination of the two is thought to be particularly detrimental. While mechanisms are multiple, the kidney is an important target of harmful effects and low potassium influences on both proximal and distal nephron segments are especially potent.
View Article and Find Full Text PDFEffect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice.
Int J Mol Sci
November 2022
Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model.
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