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CRISPR/Cas12a Corona Nanomachine for Detecting Circulating Tumor Nucleic Acids in Serum.
Anal Chem
December 2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Article Synopsis
- Circulating tumor nucleic acids (CTNAs) like cell-free DNA and RNA from tumors are potential biomarkers for cancer diagnosis and prognosis, highlighting the need for sensitive detection methods.
- The study developed a CRISPR/Cas12a nanomachine that can detect tumor DNA and RNA effectively in serum, thanks to a protective shell that prevents breakdown by enzymes.
- This innovative tool demonstrated the ability to simultaneously identify multiple types of CTNAs at very low concentrations, making it a promising method for early cancer diagnosis.
Affordable infectious pathogen detection using a dual-mode biosensor integrating exonuclease III-assisted target recycling amplification with high-throughput 96-well microplate format.
Enzyme Microb Technol
February 2025
Chemical Analysis and Biosensors Research Group, Laboratory of Process Engineering and Environment, Faculty of Sciences and Techniques, Hassan II University of Casablanca, Morocco. Electronic address:
Article Synopsis
- The proposed biosensor provides an affordable platform for detecting infectious pathogens, specifically using Hepatitis B virus (HBV) as a model.
- It utilizes an exonuclease III-assisted amplification strategy in a high-throughput 96-well format, increasing sensitivity for HBV DNA detection through repeated binding cycles.
- With a detection limit of 5.62 fM and successful quantification in human serum, this dual-mode biosensor presents a practical solution for medical diagnostics and public health monitoring.
Evaluation of a Synthetic Polyethyleneimine Based Polymeric Vector for Gene Delivery to MCF-7 Breast Cancer Cells.
Turk J Pharm Sci
November 2024
Alberta University Faculty of Engineering, Department of Chemical and Materials Engineering, Alberta, Canada.
Objectives: Breast cancer is the most common type of cancer among women and the second most common cause of death after lung cancer. The inhibitor of growth (ING) transcript levels are often suppressed in cancer cells, making it a promising candidate for cancer therapy. In this study, we aimed to formulate a polyplex that effectively carries and delivers pING4 to breast cancer cells.
View Article and Find Full Text PDFA case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure.
BMC Nephrol
November 2024
Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Karyomegalic interstitial nephritis (KIN) is a rare renal diagnosis associated with both genetic and medication etiologies. The primary gene associated with KIN is the FAN1 gene which encodes a protein responsible for DNA interstrand repair. Common medication triggers of KIN are chemotherapeutic agents, especially those which disrupt DNA structure such as carboplatin.
View Article and Find Full Text PDFA Study of the Comparability of the Pharmacodynamic, Toxicological, and Pharmacokinetic Properties of the Reference Drug Pulmozyme® and the Biosimilar Drug Tigerase®.
Dokl Biochem Biophys
October 2024
Joint-Stock Company GENERIUM (JSC GENERIUM), Volginskii settlement, 601125, Petushinskii district, Vladimir oblast, Russia.
The article presents the results of studies of the drug Tigerase® (inhalation solution manufactured by JSC GENERIUM, Russia), conducted to obtain evidence of its similarity (comparability) to the reference drug Pulmozyme® (inhalation solution, manufactured by Hoffmann-La Roche Ltd., Switzerland). Both drugs contain human recombinant deoxyribonuclease I (dornase alfa) as an active substance and are intended for the treatment of cystic fibrosis with pulmonary manifestations (mucoviscidosis).
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