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Fluorescence Probe for Detection of Malathion Using Sulfur Quantum Dots@Graphitic-Carbon Nitride Nanocomposite.
Luminescence
February 2025
BioNanocomposite Research Center, Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea.
A novel fluorescence-based sensor has been developed for the sensitive detection of malathion, an organophosphorus pesticide, using sulfur-doped quantum dots (SQDs) embedded within graphitic carbon nitride (g-C₃N₄) nanosheets. The SQDs were synthesized through a hydrothermal method, whereas the g-C₃N₄ nanosheets were produced via an exfoliation process. The resulting SQDs@g-C₃N₄ nanocomposite demonstrated outstanding performance for malathion detection in food samples, exhibiting a wide linear detection range of 10-120 μM and an exceptionally low detection limit of 0.
View Article and Find Full Text PDFFreshwater pollution: cardiotoxicity effect of perfluorooctane sulfonic acid and neonicotinoid imidacloprid mixture.
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Department of Health Sciences, "Magna Græcia University" of Catanzaro, Catanzaro, Italy.
Perfluorooctanesulfonate (PFOS) is a widely used chemical that accumulates in living things and the environment, especially the aquatic, over time. It is also known as a "forever chemical". Furthermore, different anthropogenic substances are rarely found individually in the environment.
View Article and Find Full Text PDFIn silico exploration of cholinergic activity and neuroprotection of novel caffeine analogues.
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Instituto de Investigaciones Bioquímicas de Bahía Blanca CONICET-UNS, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina. Electronic address:
Alzheimer's disease (AD) is characterized by a cholinergic deficit, prompting conventional therapies to elevate acetylcholine levels as a compensatory measure. Two main strategies involve the inhibition of acetylcholinesterase (AChE) and/or the stimulation of acetylcholine receptors (AChR). Caffeine (CFF), known as a partial agonist of nAChR and an AChE inhibitor, acts as a cholinergic enhancer.
View Article and Find Full Text PDFPotential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors.
PLoS One
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Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, Morocco.
Cognitive dysfunction in Alzheimer's disease results from a complex interplay of various pathological processes, including the dysregulation of key enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidase B (MAO-B). This study proposes and designs a series of novel molecules derived from 8-hydroxyquinoline (Azo-8HQ) as potential multi-target lead candidates for treating AD. An exhaustive in silico analysis was conducted, encompassing docking studies, ADMET analysis, density functional theory (DFT) studies, molecular dynamics simulations, and subsequent MM-GBSA calculations to examine the pharmacological potential of these molecules with the specific targets of interest.
View Article and Find Full Text PDFThe synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats.
Mol Biol Rep
January 2025
Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Background: Exposure to ionizing radiation is inevitable due to its extensive use in industrial and medical applications. The search for effective and safe natural therapeutic agents as alternatives to chemical drugs is crucial to mitigate their side effects. This study aimed to evaluate the effects of citicoline as a standalone treatment or in combination with the anti-hepatotoxic drug silymarin in protecting against liver injury caused by γ-radiation in rats.
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