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Microfluidic Cultures of Basal Forebrain Cholinergic Neurons for Assessing Retrograde Cell Death by Live Imaging.
Bio Protoc
January 2025
Department of Biological Sciences, Rutgers University, Newark, NJ, USA.
Neurons are highly polarized cells, with axons that may innervate distant target regions. In the brain, basal forebrain cholinergic neurons (BFCNs) possess extensive axons that project to several target regions such as the cortex, hippocampus, and amygdala, and may be exposed to a specific microenvironment in their axon targets that may have retrograde effects on neuronal health. Interestingly, BFCNs express the pan-neurotrophin receptor p75NTR throughout life while also concomitantly co-expressing all Trk receptors, making them capable of responding to both mature and precursor neurotrophins to promote survival or apoptosis, respectively.
View Article and Find Full Text PDFDesign, safety and efficacy evaluation of gemcitabine-eluting nanoyarn-integrated heparinized self expanding metallic stents for long-term management of malignant biliary obstruction.
Acta Biomater
January 2025
Amrita School of Nanosciences & Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India. Electronic address:
Malignant biliary obstruction presents a significant therapeutic challenge and has serious consequences including cholangitis and death. Clinically, biliary stenting using self-expanding metallic- stent(SEMS) relieves this obstruction. However, stent occlusion occurs with time due to tumor/epithelial in-growth and bacterial colonization.
View Article and Find Full Text PDFTargeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development.
Tissue Cell
December 2024
Department of Gynecology, Yantai Yuhuangding Hospital, Shandong University, Yantai, Shandong 264000, China. Electronic address:
Cervical cancer (CCA) is the predominant cause of fatalities from gynecologic malignancies, with metastasis responsible for 80 % of cancer-related mortalities. This study preliminarily examined the involvement of Sialic Acid Binding Ig Like Lectin 15 (Siglec-15) in the development of CCA and its probable mechanisms. We assessed the capacity of Siglec-15 to modulate CCA progression by establishing knockdown and overexpression Siglec-15 cell lines, supplemented with animal models, using both in vivo and in vitro dual investigations.
View Article and Find Full Text PDFA Comparison of the Apical Sealing Efficacy Between Guttaflow Bioseal and Mineral Trioxide Aggregate as Root-End Filling Materials: An In Vitro Study.
Cureus
November 2024
Department of Endodontics, Tishreen University, Lattakia, SYR.
Aim The objective of this study is to evaluate the efficacy of Guttaflow Bioseal (Coltene/Whaledent, Altstätten, Switzerland) in achieving an apical seal when utilized as a retrograde filling material in comparison to mineral trioxide aggregate (MTA). Methods Twenty single-rooted single-canaled human teeth were randomly allocated into two equal groups according to the used retrograde filling materials: Guttaflow Bioseal in group I and MTA in group II. The crowns were sectioned, and the root canals were prepared with rotary files and obturated (single cone technique with a resin-based sealer).
View Article and Find Full Text PDFSalidroside exerts neuroprotective effects on retrograde neuronal death following neonatal axotomy via activation of PI3K/Akt pathway and deactivation of p38 MAPK pathway.
Toxicol Appl Pharmacol
January 2025
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, Nantong, China. Electronic address:
Salidroside, a glucoside of tyrosol, is a powerful active ingredient extracted from the Chinese herb medicine Rhodiola rosea L.. As a neuroprotective agent, the application of salidroside in combination with neural tissue engineering has recently attracted much attention in peripheral nerve repair and reconstruction.
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