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Impact of peritoneal dialysis on weight gain in a patient with anorexia nervosa.
Perit Dial Int
January 2025
Division of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Anorexia nervosa (AN) is an eating disorder characterized by restriction of energy intake leading to a significantly low body weight, and intense fear of gaining weight. Severe electrolyte changes such as hypokalemia and hypophosphatemia; and alterations in water metabolism such as hyponatremia and edema, can occur in patients with AN. Hypokalemia and chronic volume depletion may lead to acute kidney injury (AKI) and chronic kidney disease (CKD).
View Article and Find Full Text PDFRecurrent Hypophosphatemia Following a Single Dose of Parenteral Iron Administration.
Cureus
November 2024
Acute Medicine, Royal Stoke University Hospital, Stoke-on-Trent, GBR.
Although parenteral iron is widely used to treat iron deficiency anemia (IDA), some side effects have been inadequately explored. Hypophosphatemia is becoming a well-documented, yet poorly understood, side effect of parenteral iron infusion, oftentimes causing serious and/or prolonged complications. In this article, we discuss the case of a 33-year-old female with IDA who suffered debilitating physical and mental symptoms of significant recurrent hypophosphatemia following a single standard dose of parenteral iron administration.
View Article and Find Full Text PDFSevere Hypophosphatemia Potentially Associated with Intracellular Phosphate Shift Concomitant with Acute Kidney Injury in a Patient with Rapidly Proliferating Diffuse Large B-cell Lymphoma.
Intern Med
November 2024
Department of Nephrology, Shimane Prefectural Central Hospital, Japan.
An 85-year-old woman with diffuse large B-cell lymphoma developed severe hypophosphatemia (serum phosphate 0.3 mg/dL) concomitant with acute kidney injury (serum creatinine 2.05 mg/dL) following chemotherapy.
View Article and Find Full Text PDFSevere hypophosphatemia induced by excessive production of FGF23 in acute hepatitis: from bedside to bench.
Clin Kidney J
November 2024
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, France.
Background: Although hepatic production of FGF23 has been suggested in chronic settings, there are no data indicating hypophosphatemia resulting from acute hepatic FGF23 production. Based on two clinical observations of profound hypophosphatemia in the setting of acute hepatitis, our study investigates the hypothesis of acute FGF23 liver expression.
Methods: Retrospective analyses were conducted to estimate FGF23 liver expression both qualitatively ( hybridization) and quantitatively (relative FGF23 gene expression and protein production) on histological specimens of human and murine acute hepatitis livers, compared with controls of hepatic fibrosis or healthy liver.
Costs of Adverse Events in Patients with Advanced or Metastatic Renal Cell Carcinoma with First-Line Treatment.
Pharmacoecon Open
November 2024
Bristol Myers Squibb, Princeton, NJ, USA.
Article Synopsis
- This study investigates the costs associated with adverse events (AEs) in untreated patients with advanced renal cell carcinoma (aRCC) in the USA, analyzing a large dataset from 2014 to 2021.
- The research involved 1,681 patients and found that a significant majority experienced at least one AE, leading to increased medical costs; expenses for these AEs varied widely, from under $300 to nearly $60,000.
- The study highlights limitations of observational data but emphasizes the financial impact of AEs on the treatment of aRCC, especially those costing over $10,000 within 30 days of diagnosis.
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