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Distinct Hemostasis and Blood Composition in Spiny Mouse .
Int J Mol Sci
November 2024
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Article Synopsis
- The spiny mouse exhibits the ability to heal wounds without scarring, which may be linked to unique features of its blood and clotting mechanisms.
- Compared to Balb/c mice, spiny mice showed stronger blood clots, faster tail bleeding times, and higher levels of clottable fibrinogen, indicating superior hemostatic capabilities.
- Histological analysis revealed that spiny mouse clots were densely packed with fibrin and had better plasma clot stiffness, suggesting that these characteristics could enhance their wound healing and regenerative abilities.
Viscoelastic testing of fibrinolytic capacity in acutely infected critically ill patients: Protocol for a scoping review.
Acta Anaesthesiol Scand
January 2025
Intevnsive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Liverpool, New South Wales, Australia.
Introduction: Viscoelastic testing (VET) has been implemented in clinical care to diagnose and manage coagulation in patients with manifest or high risk of major bleeding. However, the breakdown of formed blood clots, that is, fibrinolysis, has been comparatively less studied. There is an increasing recognition that acute infections trigger a dysregulated immunothrombotic response, which has focused attention on viscoelastic testing to identify in particular fibrinolysis resistant states.
View Article and Find Full Text PDFViscoelastic Hemostatic Testing as a Diagnostic Tool for Hypercoagulability in Liver Transplantation: A Narrative Review.
J Clin Med
October 2024
Medical Director, Tem Innovations GmbH, 81829 Munich, Germany.
Liver transplantation is a complex surgical procedure in which various forms of coagulation dysfunction can occur, including perioperative hypercoagulability. The hemostasis balance in liver graft recipients with end-stage liver disease can shift to thrombosis or haemorrhage, depending on the associated risk factors and clinical conditions. Hypercoagulability can result in serious complications such as thromboembolism, which can affect the vessels of the newly transplanted liver graft.
View Article and Find Full Text PDFUtility of thromboelastography with platelet mapping for monitoring platelet transfusion in qualitative platelet disorders.
J Thromb Haemost
October 2024
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA; Blood Research Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address:
Background: Patients with pathogenic variants in RASGRP2 (inherited platelet disorder (IPD)-18) exhibit normal platelet counts but impaired platelet aggregation and αβ activation. Moderate-to-severe bleeding episodes require patients to be transfused with platelets and/or pro-hemostatic agents. We recently demonstrated that hemostatic efficacy of transfused platelets is limited by dysfunctional endogenous platelets in a mouse model of IPD-18 (Rasgrp2 mice), as dysfunctional platelets were recruited to the forming hemostatic plug but did not participate in clot contraction.
View Article and Find Full Text PDFTargeting tissue factor pathway inhibitor with concizumab to improve hemostasis in patients with Glanzmann thrombasthenia: an in vitro study.
J Thromb Haemost
September 2024
Department of Haematology, University Hospital of Bordeaux, Pessac, France; Institut National de la Santé et de la Recherche Médicale U1034, Biology of Cardiovascular Disease, Pessac, France; French Reference Centre for Inherited Platelet Disorders, University Hospital of Bordeaux, Pessac, France. Electronic address:
Background: Glanzmann thrombasthenia (GT) is caused by an inherited defect of platelet αβ integrin. Concizumab, a monoclonal antibody specific for tissue factor pathway inhibitor, abolishes its anticoagulant effect.
Objectives: To evaluate the in vitro ability of concizumab to improve hemostasis in GT.
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