An analysis has been given of the first 500 cases submitted to the Placental Tissue Registry. Placental lesions were studied in a variety of clinical situations other than the usual complications of pregnancy. There were more infant deaths than infants with a good outcome in the cases of absence of one umbilical artery, amnion nodosum, atheromatosis of the decidual vessels, and acute and chronic villitis. The etiology of chronic villitis remains obscure.
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