An apparatus is described allowing multichannel connection with unrestrained animals without using joints. The twisting of the connection lines caused by the rotation of the animal in its cage is detected by means of a torsion wire connected to an electronic device. This provokes a temporized rotation of the bottom of the cage in the opposite direction in order to untwist the lines.
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http://dx.doi.org/10.1152/ajpgi.1981.240.3.G250 | DOI Listing |
Acta Trop
January 2025
Clinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
The Anthropocene era is marked by unprecedented human-induced alterations to the environment, resulting in a climate emergency and widespread ecological deterioration. A staggering number of up to one million species of plants and animals are in danger of becoming extinct, which includes over 10 % of insect species and 40 % of plant species. Unrestrained release of greenhouse gases, widespread deforestation, intense agricultural practices, excessive fishing, and alterations in land use have exceeded the ecological boundaries that were once responsible for humanity's wellbeing.
View Article and Find Full Text PDFHematology
December 2025
The Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming, Yunnan Province, People's Republic of China.
To investigate the role of ALKBH3 in acute myeloid leukemia (AML), we constructed an animal model of xenotransplantation of AML. Our study demonstrated that ALKBH3-mediated m1A demethylation inhibits ferroptosis in KG-1 cells by increasing ATF4 expression, thus promoting the development of AML. These findings suggest that reducing ALKBH3 expression may be a potential strategy to mitigate AML progression.
View Article and Find Full Text PDFCells
December 2024
Neural Dynamics Laboratory, Department of Medicine, The University of Melbourne, Melbourne, VIC 3052, Australia.
Neurological disorders (NDs), such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and schizophrenia, represent a complex and multifaceted health challenge that affects millions of people around the world. Growing evidence suggests that disrupted neuronal calcium signalling contributes to the pathophysiology of NDs. Additionally, calcium functions as a ubiquitous second messenger involved in diverse cellular processes, from synaptic activity to intercellular communication, making it a potential therapeutic target.
View Article and Find Full Text PDFNeuroscience
January 2025
Center for Consciousness Science, Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address:
J Neural Eng
November 2024
Institute of Biomedical Engineering, Boğaziçi University, İstanbul 34684, Turkey.
Brain-computer interfaces (BCI) are promising for severe neurological conditions and there are ongoing efforts to develop state-of-the-art neural interfaces, hardware, and software tools. We tested the potential of novel reduced graphene oxide (rGO) electrodes implanted epidurally over the hind limb representation of the primary somatosensory (S1) cortex of rats, and compared them to commercial platinum-iridium (Pt-Ir) 16-channel electrodes (active site diameter: 25m).Motor and somatosensory information was decoded offline from microelectrocorticography (ECoG) signals recorded while unrestrained rats performed a simple behavioral task: pressing a lever and the subsequent vibrotactile stimulation of the glabrous skin at three displacement amplitude levels and at two sinusoidal frequencies.
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