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Improving the early detection of aphasia in the acute phase of stroke: the contribution of a screening test.
Brain Inj
January 2025
Faculté de médecine, École des Sciences de la réadaptation, Université Laval, Québec, Canada.
Background: Aphasia is one of the most common and most debilitating after-effects of a stroke. In the acute phase of a stroke, referrals to speech-language pathology (SLP) are frequently guided by clinical impressions rather than validated tests.
Objectives: This study aimed to evaluate the advantages of incorporating the Screening test for language disorders in adults and the elderly (DTLA) into clinical practice for detecting language disorders during the acute phase of stroke.
Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance.
Neuron
December 2024
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. Electronic address:
Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit responsible for passivity.
View Article and Find Full Text PDFA single exposure to prolonged flexor carpi radialis muscle vibration increases sensorimotor cortical areas activity.
J Neurophysiol
January 2025
Laboratoire Interuniversitaire de Biologie de la Motricité, Université Jean Monnet Saint-Etienne, Lyon 1, Université Savoie Mont-Blanc, Saint-Etienne, France.
Prolonged local vibration (LV) is thought to promote brain plasticity through repeated Ia afferents discharge. However, the underlying mechanisms remain unclear. This study therefore aimed at determining the acute after-effects of 30-min LV of the flexor carpi radialis muscle (FCR) on sensorimotor (S1, M1) and posterior parietal cortex (PPC) areas activity.
View Article and Find Full Text PDFFunctional resistance training during walking: do biomechanical and neural effects differ based on targeted joints?
IEEE Trans Med Robot Bionics
May 2024
Michigan Medicine Department of Physical Medicine and Rehabilitation and the University of Michigan Robotics Institute, Ann Arbor, MI, 48108.
Devices for functional resistance training (FRT) during walking are often configured to resist the knee or both the hip and knee joints. Adding resistance to the hip in addition to the knee should alter the effects of training; however, these configurations have not been directly compared. We examined how FRT during walking differs during the knee or hip and knee conditions.
View Article and Find Full Text PDFThe Potential Effects of 2,3,4-Trihydroxybenzophenone on the Transient Cerebral Ischemic Stroke in Male Mice.
Biol Pharm Bull
November 2024
Department of Advanced Translational Medicine, Konkuk University.
Acute ischemic stroke is a cerebrovascular disease associated with high mortality and severe aftereffects which is caused by the blockage of cerebral blood vessels by a thrombus or embolus. Treatments for this condition are extremely limited. Herein, we aimed to explore the potential of 2,3,4-trihydroxybenzophenone (THB), a drug that suppresses oxidative stress and neuroinflammation, to promote functional recovery through neurite outgrowth, and to identify its protective effects in a mouse model of ischemic stroke.
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